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UC researchers open Phase 2 clinical trial to test new combination treatment for glioblastomas

A multidisciplinary team of University of Cincinnati Cancer Center researchers have opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas (GBM), the most deadly form of brain tumors.

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Case Western Reserve University

Case Western Reserve UniversityNews, press releases, and expert sources for journalists in science, medicine & business

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Cushion, Smulian Earn Prestigious Catalyst Research Award

Cushion, Smulian Earn Prestigious Catalyst Research Award
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Falk Trust awards $1.35 million to Case Western Reserve researchers for cancer and diabetic retinopathy treatments

A combined $1.35 million from the Dr. Ralph and Marian Falk Medical Research Trust was awarded to two researchers from the Case Western Reserve University School of Medicine to advance their work on finding more effective treatments-;and better options-;for two debilitating diseases.

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MSU drug developers win seed funding for development of cancer, tuberculosis drugs

Two biomedical researchers at MSU have received a total of $600,000 in high-risk, high-reward Catalyst Awards from the Dr. Ralph and Marian Falk Medical Research Trust.

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Commonly prescribed cholesterol-lowering drugs could be effective in treating ulcerative colitis

Commonly prescribed cholesterol-lowering drugs could be effective in treating ulcerative colitis
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Nanotech Jumps Blood-Brain Barrier To Kill Cancer in Mice

Nanotech Jumps Blood-Brain Barrier To Kill Cancer in Mice
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research shows.

The study is the first to demonstrate an intravenous medication that can cross the blood-brain barrier.
I’ve worked in this field for more than 10 years and have not seen anything like this.
The discovery could one day allow new clinical therapies for treating glioblastoma, the most common and aggressive form of brain cancer in adults, and one whose incidence is rising in many countries. Today’s median survival for patients with glioblastoma is around 18 months; the average 5-year survival rate is below 5%.

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Mission to MAARS: Long non-coding RNA may play a key role in cardiovascular disease

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Atherosclerosis is marked by the buildup of inflammatory cells which narrow arteries to the point of chest pain and muscle weakness. Severe cases result in lesions and internal ruptures of arteries or even thrombosis in coronary arteries. One way that investigators are working to understand how atherosclerosis occurs and progresses is by looking at long non-coding RNAs (lncRNAs), strands of RNA that are not translated into proteins and which may play integral but understudied roles in cell regulation and disease progression. Through utilization of genetically modified high-risk atherosclerotic mice, a research team from Brigham and Women's Hospital identified and characterized Macrophage-Associated Atherosclerosis lncRNA Sequence (MAARS), which is expressed specifically in macrophages in atherosclerotic plaques and contributes to the progression of the disease. Results are published in

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Collaboration Driving Progress: LLS Forms Alliances with Leading Cancer Institutions and Foundations to Co-Fund nearly $17 million in New Research Grants

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RYE BROOK, N.Y., Dec. 14, 2020 /PRNewswire/ -- As the world confronts a viral pandemic not seen in the past 100 years, the reverberations are being felt across every sector, from healthcare to the economy, education, business and science, including the blood cancer community. Blood cancers don't stop for the Covid-19 virus and the urgent need for collaboration to address these challenges has never been starker.
In response, The Leukemia & Lymphoma Society (LLS) today announced it has forged significant alliances with premier foundations, cancer institutions and philanthropic individuals, bringing their collective resources to bear to co-fund approximately $9 million in new research grants, with up to $8 million more funding anticipated over the next year. This cooperation will allow LLS to continue driving forward impactful research to find better treatments and cures for patients with leukemia, lymphoma, myeloma and other blood cancers.

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