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Targeted therapies could exploit unique metabolic features of pancreatic cancer cells


Targeted therapies could exploit unique metabolic features of pancreatic cancer cells
Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them.
Led by Princess Margaret Cancer Centre (PM) Scientist Dr. Marianne Koritzinsky, researchers showed that about half of patient-derived pancreatic cancer cell lines are highly dependent or addicted to the protein peroxiredoxin 4 (PRDX4), as a result of the altered metabolic state of the cancer cell.
This addiction is vital for the cancer cell s survival, thereby also making it a precise, potential target against the cancer. ....

United States , Marianne Koritzinsky , David Hedley , Jason Moffat , Emily Henderson , University Of Toronto , Princess Margaret Cancer Centre Pm Scientist , Institute Of Medical Science , American Association For The Advancement Of Science , Princess Margaret Cancer Centre Pm Scientist Dr , Donnelly Centre For Cellular , Biomolecular Research , Princess Margaret Cancer Centre , Science Advances , American Association , Associate Professor , Radiation Oncology , Medical Biophysics , Medical Science , Donnelly Centre , Staff Physician , Princess Margaret , ஒன்றுபட்டது மாநிலங்களில் , டேவிட் ஹெட்லி , ஜேசன் மாஃபேட் , எமிலி ஹென்டர்சன் ,