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Four and a half years ago, Parnham House in Dorset was reduced by fire to a smouldering shell a catastrophe followed by the arrest of its owner, Austrian banker Michael Treichl, for suspected arson, and his subsequent death by drowning in Lake Geneva. But what promises to be one of Britain s most daring and innovative architectural resurrections is now in hand thanks to the man dubbed the new Leonardo of design . Thomas Heatherwick is the creator of the stunning cauldron at the 2012 London Olympics, as well as an array of buildings and bridges around the world. Parnham House in Dorset pictured before a devastating fire reduced it to a smouldering hell ....
Incorporating Excipients Into QbD Studies For Drug Development â An Introduction By Brian Carlin (DFE Pharma), Chris Moreton (FinnBrit Consulting), Dave Schoneker (Black Diamond Consulting), Katherine Ulman (KLU Consulting), Joseph Zeleznik (IMCD) This article is the first in a three-part series based on information from the new guide Incorporation of Pharmaceutical Excipients into Product Development using Quality-by-Design , published by the International Pharmaceutical Excipients Council Federation (IPEC Federation). 1 The International Conference on Harmonization’s (ICH) guidelines related to quality by design (QbD) primarily ICH Q8, as well as Q9, Q10, Q11, and Q12 2-6 are high level and focus on the active pharmaceutical ingredient (API) and finished drug product. Applying API logic to excipients can lead to counterproductive adaptations inconsistent with QbD principles. ....
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