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Engineered safety switch curbs severe side effects of CAR-T immunotherapy

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IMAGE: Matthew Foster, MD, and his UNC Lineberger colleagues have used an experimental safety switch incorporated as part of a chimeric antigen receptor-modified T cell therapy (CAR-T) for an aggressive form.
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Credit: UNC Lineberger Comprehensive Cancer Center
CHAPEL HILL, North Carolina UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur. This advance was seen in a patient enrolled in a clinical trial using CAR-T to treat refractory acute B-cell leukemia. It demonstrates a proof-of-principle for possible expanded use of CAR-T immunotherapy paired with the safety switch. ....

Winnie Lau , Natalie Grover , Robert Hagan , Anastasia Ivanova , Brianne Buchanan , Matthew Foster , Daiichi Sankyo , Kaitlin Morrison , Catherine Cheng , James Coghill , Spencer Laing , Aaron Foster , Paul Armistead , John West , Barbara Savoldo , Jonathan Serody , Lineberger Cellular Immunotherapy Program , Gillings School Of Global Public Health , School Of Medicine , Bellicum Pharmaceuticals , Marsico Lung Institute , University Cancer Research Fund , Merck Inc , Advisory Board Of Kite Pharmaceuticals , Cellular Immunotherapy Program , Lineberger Comprehensive Cancer Center ,

Tracking Israeli Involvement: University of North Carolina generated COVID-19 (censored/suppressed) – Veterans Today | Military Foreign Affairs Policy Journal for Clandestine Services

Tracking Israeli Involvement: University of North Carolina generated COVID-19 (censored/suppressed) – Veterans Today | Military Foreign Affairs Policy Journal for Clandestine Services
veteranstoday.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from veteranstoday.com Daily Mail and Mail on Sunday newspapers.

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