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Early use of anakinra reduces risk of mortality for patients with COVID-19 pneumonia, reduces ICU admission and increases likelihood of full recovery


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- Day 28 full results from the SAVE-MORE study show early treatment with anakinra plus SOC (standard of care) reduced mortality by 55% and reduced average time until ICU (intensive care unit) discharge by four days
- Day 28 full results from the SAVE-MORE study show early treatment with anakinra plus SOC (standard of care) reduced mortality by 55% and reduced average time until ICU (intensive care unit) discharge by four days
- In patients treated with anakinra plus SOC, overall clinical status improved by 64% compared to those treated with SOC alone
- The SAVE-MORE trial, conducted by the Hellenic Institute for the Study of Sepsis, is the first large, pivotal randomised controlled trial to specifically evaluate a target patient population with COVID-19 at risk of progressing and demonstrating the benefit of earlier intervention with anakinra for the prevention of disease progression and reduced risk of mortality ....

United States , Kostenloser Wertpapierhandel , Maria Kruse , Evangelosj Giamarellos Bourboulis , Paula Treutiger , Guido Oelkers , European Shock Society , World Health Organization , Hellenic Institute For The Study Of Sepsis , Kapodistrian University Of Athens , European Sepsis Alliance , Hellenic Institute , Internal Medicine , Infectious Diseases , Kapodistrian University , European Sepsis , Progression Scale , Odds Ratio , Guided Anakinra Treatment , Severe Respiratory Failure , Professor Giamarellos Bourboulis , Familial Mediterranean , Systemic Juvenile Idiopathic Arthritis , Adult Onset Still , Intensive Care Units , North America ,

Spatial distribution and determinant factors of anemia among adults aged 15–59 in Ethiopia; using mixed-effects ordinal logistic regression model


Background
Anemia is a global public health problem, particularly in developing countries. Assessing the geographic distributions and determinant factors is a key and crucial step in designing targeted prevention and intervention programmes to address anemia. Thus, the current study is aimed to assess the spatial distribution and determinant factors of anemia in Ethiopia among adults aged 15–59.
Methods
A secondary data analysis was done based on 2016 Ethiopian Demographic and Health Surveys (EDHS). Total weighted samples of 29,140 adults were included. Data processing and analysis were performed using STATA 14; ArcGIS 10.1 and SaTScan 9.6 software. Spatial autocorrelation was checked using Global Moran’s index (Moran’s I). Hotspot analysis was made using Gettis-OrdGi statistics. Additionally, spatial scan statistics were applied to identify significant primary and secondary cluster of anemia. Mixed effect ordinal logistics were fitted to determine factors associ ....

Gambela Hizboch , Addis Ababa , Dire Dawa , Health Surveys , East African , Southern Nations , People Region , Addis Ababa City , Housing Census , Body Mass Index , Personal Record , Global Moran , Bayesian Information Criteria , Information Criteria , Odds Ratio , Confidence Interval , மோசமான தாவா , ஆரோக்கியம் ஆய்வுகள் , தெற்கு நாடுகள் , மக்கள் பகுதி , வீட்டுவசதி மக்கள் தொகை கணக்கெடுப்பு , உடல் நிறை குறியீட்டு , தனிப்பட்ட பதிவு , உலகளாவிய மோரன் , தகவல் அளவுகோல்கள் , முரண்பாடுகள் ரேஶியோ ,