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NIH-funded clinical trial begins study of systemic allergic reactions to COVID-19 vaccines


NIH-funded clinical trial begins study of systemic allergic reactions to COVID-19 vaccines
A clinical trial is underway to determine whether people who are highly allergic or have a mast cell disorder are at increased risk for an immediate, systemic allergic reaction to the Moderna or Pfizer-BioNTech COVID-19 vaccines. A systemic allergic reaction to a vaccine occurs in one or more parts of the body beyond the injection site. If such an allergic reaction occurs in study participants, investigators will assess whether the reactions are more frequent in participants who are highly allergic or have a mast cell disorder than in participants with no allergic history. In addition, investigators will examine the biological mechanism behind the reactions and whether a genetic pattern or other factors can predict who is at most risk. ....

New York , United States , United Kingdom , Jamesr Baker Jr , Rebeccas Gruchalla , N Franklin Adkinson Jr , Ruth Dow Doan , Anthonys Fauci , Emily Henderson , Johns Hopkins Asthma Allergy Center , Us Department Of Defense , Us Department Of Health , Human Services , National Institute Of Allergy , National Institutes Of Health , Drug Administration , Maryh Weiser Food Allergy Center , Pfizer Inc , Moderna Inc , National Institute , Infectious Diseases , National Institutes , Systemic Allergic Reactions , Johns Hopkins Asthma , Allergy Center , Food Allergy Center ,

NIH begins study of allergic reactions to Moderna, Pfizer-BioNTech COVID-19 vaccines


Adults interested in participating in this trial should visit ClinicalTrials.gov and search under study identifier 
 for study locations and contacts. Please do not use the NIAID media phone number or email address to try to enroll in this trial.  
Colorized scanning electron micrograph of a cell (orange) infected with UK B.1.1.7 variant SARS-CoV-2 virus particles (green), isolated from a patient sample.NIAID
A clinical trial is underway to determine whether people who are highly allergic or have a mast cell disorder are at increased risk for an immediate, systemic allergic reaction to the Moderna or Pfizer-BioNTech COVID-19 vaccines. A systemic allergic reaction to a vaccine occurs in one or more parts of the body beyond the injection site. If such an allergic reaction occurs in study participants, investigators will assess whether the reactions are more frequent in participants who are highly allergic or have a mast cell disorder than in participants with no aller ....

New York , United States , United Kingdom , Jamesr Baker Jr , Rebeccas Gruchalla , N Franklin Adkinson Jr , Ruth Dow Doan , Anthonys Fauci , Johns Hopkins Asthma Allergy Center , Us Department Of Defense , Us Department Of Health , Human Services , National Institute Of Allergy , National Institutes Of Health , Drug Administration , Maryh Weiser Food Allergy Center , Pfizer Inc , Moderna Inc , National Institute , Infectious Diseases , National Institutes , Systemic Allergic Reactions , Johns Hopkins Asthma , Allergy Center , Food Allergy Center , Ruth Dow Doan Professor ,