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CHOP researchers identify two proteins that could be used for a potential NTHi vaccine


CHOP researchers identify two proteins that could be used for a potential NTHi vaccine
Scientists at Children s Hospital of Philadelphia (CHOP) have identified two proteins that could be used for a potential vaccine against nontypeable
Haemophilus influenzae (NTHi). Working in a mouse model, the investigators found that administering two bacterial adhesive proteins that play a key role in helping the bacteria to latch on to respiratory cells and initiate respiratory tract infection stimulated protective immunity against diverse NTHi strains, highlighting the vaccine potential.
The findings were published today in the
Proceedings of the National Academy of Sciences.
Nontypeable
Haemophilus influenzae is the most common cause of bacterial respiratory tract infections such as middle ear infections, sinus infections, and exacerbations of chronic obstructive pulmonary disease (COPD) and other underlying lung disease, resulting in significant morbidity in both ....

United States , Nontypeable Haemophilus , Emily Henderson , Proceedings Of The National Academy Sciences , National Academy , Senior Study Author , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , தேசிய கலைக்கழகம் , மூத்தவர் படிப்பு நூலாசிரியர் ,

Diet and lifestyle may play a significant role in Alzheimer's disease


Diet and lifestyle may play a significant role in Alzheimer s disease
For years, research to pin down the underlying cause of Alzheimer s Disease has been focused on plaque found to be building up in the brain in AD patients. But treatments targeted at breaking down that buildup have been ineffective in restoring cognitive function, suggesting that the buildup may be a side effect of AD and not the cause itself.
A new study led by a team of Brigham Young University researchers finds novel cellular-level support for an alternate theory that is growing in strength: Alzheimer s could actually be a result of metabolic dysfunction in the brain. In other words, there is growing evidence that diet and lifestyle are at the heart of Alzheimer s Disease. ....

Benjamin Bikman , Emily Henderson , Brigham Young University , Senior Study Author , Developmental Biology , Brigham Young , Alzheimer 39s Disease , Cognitive Function , Glucose Metabolism , Insulin Resistance , Nervous System , எமிலி ஹென்டர்சன் , ப்ரிகாம் இளம் பல்கலைக்கழகம் , மூத்தவர் படிப்பு நூலாசிரியர் , வளர்ச்சி உயிரியல் , ப்ரிகாம் இளம் , அறிவாற்றல் செயல்பாடு , நீரிழிவு நோய் , இன்சுலின் எதிர்ப்பு , வளர்சிதை மாற்றம் , பதட்டமாக அமைப்பு ,

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis


Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis
Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurons disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s.
When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behavior. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons.
Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change. ....

Oliver Ziff , Rickie Patani , Emily Henderson , National Hospital For Neurology , Queen Square Institute Of Neurology , Group Leader , Nucleic Acids Research , Francis Crick Institute , Senior Study Author , Queen Square Institute , Consultant Neurologist , National Hospital , Square Institute , Motor Neurone Disease , Amyotrophic Lateral Sclerosis , Genetic Information , Motor Neurons , Nervous System , Neurodegenerative Diseases , Stem Cells , ஆலிவர் ஸிஃப் , ரிக்கி படானி , எமிலி ஹென்டர்சன் , தேசிய மருத்துவமனை க்கு நரம்பியல் , ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல் , குழு தலைவர் ,

Forest Devices publishes positive results from study of its AlphaStroke technology


Forest Devices publishes positive results from study of its AlphaStroke technology
Feb 25 2021
Medical technology pioneer Forest Devices, Inc. (FDI) today announced the publication of positive results from the EDGAR study of its AlphaStroke™ technology in identifying patients with large vessel occlusive (LVO) strokes in emergency departments in the American Heart Association Journal,
STROKE. LVOs are the type of ischemic stroke that require an interventional thrombectomy, only available at highly specialized hospitals, and every minute of treatment delay increases the risk of death and permanent disability.
The study showed that, compared to the clinical exams currently used by medics in the field to make triage decisions, AlphaStroke was 28% - 40% superior at correctly identifying patients with LVO, and equally good as the clinical exams, at correctly ruling out patients with non-LVO diagnoses. ....

United States , Baylor College Of Medicine , Matt Kesinger , Paulina Sergot , Frank Peacock , Forest Devices Inc , American Heart Association Journal , Research Of Emergency Medicine , Forest Devices , Emergency Medicine , Memorial Hermann , Senior Study Author , Vice Chair , Baylor College , Ischemic Stroke , ஒன்றுபட்டது மாநிலங்களில் , பேலர் கல்லூரி ஆஃப் மருந்து , வெளிப்படையான மயில் , காடு சாதனங்கள் இன்க் , அமெரிக்கன் இதயம் சங்கம் இதழ் , ஆராய்ச்சி ஆஃப் அவசரம் மருந்து , காடு சாதனங்கள் , அவசரம் மருந்து , நினைவகம் ஹெர்மன் , மூத்தவர் படிப்பு நூலாசிரியர் , துணை நாற்காலி ,