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Intratumoral SIRPalpha-deficient macrophages activate tumor-specific cytotoxic T cells

In a study that will be published in Nature Communications on May 28, 2021, a research team led by Dr. Yuan Liu from Georgia State University reports that intratumoral SIRPalpha-deficient macrophages activate tumor antigen-specific cytotoxic T cells to eliminate various syngeneic cancers under radiotherapy. Their study identifies SIRPalpha as a master regulator controling macrophage immune responses and has demonstrated that intratumoral injection of SIRPalpha-depleted macrophages combined with local radiation is an effective strategy to treat different tumors ....

United States , Georgia State University , Ahmedt Abdelaal , Koby Kidder , Charlie Garnett Benson , Venture Development , National Institutes Of Health , Program Of Cancer , Nature Communications On , Research Scholar Grant , American Association Of Immunologist , American Cancer Society , Georgia Research Alliance , Nature Communications , Yuan Liu , Zhen Bian , Lei Shi , National Institutes , Biolocity Innovation , American Association , Molecular Basis , Molecular Genetics , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , ஜார்ஜியா நிலை பல்கலைக்கழகம் , துணிகர வளர்ச்சி ,

Could camel milk be key to developing new drugs to combat diabetes?

UAE research has delved deep into the positive effects of camel milk for diabetics
Camels, seen here compete in the beauty pageant of the annual King Abdulaziz Camel Festival in Rumah, could have a crucial role to play in the fight against diabetes. AFP
Camels compete in the beauty pageant of the annual King Abdulaziz Camel Festival in Rumah. AFP
Camels compete in the beauty pageant of the annual King Abdulaziz Camel Festival in Rumah. AFP
Camels rest during the beauty pageant of the annual King Abdulaziz Camel Festival in Rumah. AFP
Camels compete in the beauty pageant of the annual King Abdulaziz Camel Festival in Rumah. AFP ....

United Arab Emirates , Sajid Maqsood , Mohammed Ayoub , Zayed Centre For Health Sciences , Middle East , Molecular Basis , Antidiabetic Properties , Camel Milk Through Profiling , Bioactive Peptides , Insulin Receptor Activity , United Arab Emirates University , Food Science , Zayed Centre , ஒன்றுபட்டது அரபு அமீரகங்கள் , சஜித் மக்ஸுட் , முகமது அயூப் , நடுத்தர கிழக்கு , மூலக்கூறு அடிப்படையில் , ஒன்றுபட்டது அரபு அமீரகங்கள் பல்கலைக்கழகம் , உணவு அறிவியல் , ஸேயெட் மையம் ,

Covid variants story can't be used to keep us oppressed

Covid variants story can't be used to keep us oppressed
conservativewoman.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from conservativewoman.co.uk Daily Mail and Mail on Sunday newspapers.

United States , United Kingdom , Jasona Greenbaum , Emilya Teslow , Edwardc Holmes , Julianes Walz , Ellen Shrock , Mehuls Suthar , N Le Bert , Swapnil Mahajan , John Pa Ioannidis , Yale University , British Society For Immunology , Advisory Committee On Immunization Practices , University Hospital , Global Initiative On Sharing Avian Influenza Data , Jolla Institute For Immunology , Global Initiative , Sharing Avian Influenza , Molecular Basis , Molecular Cell , Nature Microbiology , British Society , Antibody Response , Medical Affairs , Nat Rev Immunol ,

Frontiers | The CD147 Protein Complex Is Involved in Entry of Chikungunya Virus and Related Alphaviruses in Human Cells

2Laboratory for Pharmaceutical Biotechnology, University of Ghent, Ghent, Belgium
3ProGenTomics, Ghent, Belgium
4Laboratory of Proteinscience, Proteomics and Epigenetic Signaling, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
5Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
Chikungunya virus (CHIKV) is an arbovirus with a global spread and significant public health impact. It is a positive stranded RNA alphavirus belonging to the
Togaviridae family. However, many questions about the replication cycle of CHIKV remain unanswered. The entry process of CHIKV is not completely understood nor are the associated virus-receptor interactions fully identified. Here, we designed an affinity purification mass spectrometry coupled approach that allowed the identification of factors that facilitate entry of CHIKV in human cells. The identified entry factors were further validated using CRISP ....

United States , South Africa , Provence Alpes Côd Azur , Basse Normandie , Krung Thep Mahanakhon , Ubon Ratchathani , Haute Normandie , South African , Mohamed Hussain , Hela Matusali , Indian Ocean , Tatsuo Shioda Mahidol , Feng Zhang , Institute Of Technology , Andres Merits University Of Tartu , Kosaka Center , Research Fund Flanders , Mahidol University , National Collection Of Pathogenic Viruses , West African , Saharan Africa , Modified Eagle , National Collection , Pathogenic Viruses , Lithium Chloride , Streptavidin Sepharose High Performance ,

The puzzle of nonhost resistance: why do pathogens harm some plants but not others?

Credit: Ralph Panstruga & Matthew Moscou
People have puzzled for years why pathogen
Phytophthora infestens causes the devastating late blight disease, source of the Irish Potato famine, on potatoes, but has no effect at all on plants like apple or cucumber. How are apple trees and cucumber plants able to completely shake off this devastating pathogen? Agricultural scientists have wondered for years: if this resistance is so complete and persists over so many generations, is there some way we could transfer it to susceptible plants like wheat and thereby stop disease?
Why is it so important to determine the molecular basis of nonhost resistance? ....

Glasgow City , United Kingdom , Ralph Panstruga , Aachen University , Sainsbury Laboratory In Norwich , International Congress On Molecular Plant , Irish Potato , Matthew Moscou , Sainsbury Laboratory , Molecular Basis , Molecular Plant Microbe Interactions , கிளாஸ்கோ நகரம் , ஒன்றுபட்டது கிஂக்டம் , ஆச்சென் பல்கலைக்கழகம் , சைன்ஸ்பரி ஆய்வகம் இல் நார்விச் , சர்வதேச காங்கிரஸ் ஆன் மூலக்கூறு ஆலை , ஐரிஷ் பொட்யாடோ , சைன்ஸ்பரி ஆய்வகம் , மூலக்கூறு அடிப்படையில் , மூலக்கூறு ஆலை நுண்ணுயிர் இடைவினைகள் ,