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SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation
A team of scientists from Italy and the USA has recently explored the maturation pattern of conventional dendritic cells (cDCs) during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that the virus efficiently escapes host immune responses by directly interacting with cDCs and disrupting T cell activation. The study is currently available on the
Background
Since its emergence in December 2019 in China, SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), has infected 114 million people and claimed 2.5 million lives worldwide. In its milder form, COVID-19 is mainly associated with fever, dry cough, sore throat etc. However, a severe form of the disease often leads to serious health complications characterized by cardiovascular, pulmonary, and metabolic disorders. In general, COVID-19 patients with severe symptoms exhibit s ....

United States , Sanchari Sinha Dutta , Principal Component Analysis , Coronavirus Disease Covid 19 , Dendritic Cell , Sars Cov 2 , Corona Virus , Metabolic Disorders , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Sore Throat , ஒன்றுபட்டது மாநிலங்களில் , சஞ்சரி சீன்ஹா தத்தா , ப்ரிந்ஸிபல் கூறு பகுப்பாய்வு , கொரோனா வைரஸ் , வளர்சிதை மாற்ற கோளாறுகள் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , புண் தொண்டை ,

Identification of neutralizing IFNL3 autoantibodies in severe COVID-19 cases

Identification of neutralizing IFNL3 autoantibodies in severe COVID-19 cases
Scientists believe that an unbiased analysis of antibody binding sites would provide significant insights into health and disease states. In this regard, many researchers have utilized programmable phage display libraries to detect novel autoantibodies. Phage display libraries have been used to characterize anti-viral immunity and profile allergen-specific Immunoglobulin E (IgE) antibodies.
Even though protein microarrays are extremely useful for protein research, the high per-assay cost and numerous technical artifacts make them less user-friendly. Technologies such as Nucleic Acid Programmable Protein Array (NAPPA) and single-molecule PCR-linked in vitro expression (SIMPLEX) are effective but not cost-effective. ....

Priyom Bose , Halotag Haloligand , Self Assembly , Nucleic Acid Programmable Protein Array , Using Molecular Indexing , Image Credit , Preprint Graphical Abstract , Parallel Analysis , Translated Open , Molecular Indexing , N Terminal Halotag , Coronavirus Disease Covid 19 , Sars Cov 2 , High Throughput , In Vitro , Nucleic Acid , பிரீயோம் போஸ் , சுய சட்டசபை , படம் கடன் , இணையாக பகுப்பாய்வு , இல் விட்ரோ ,

Cell surface marker CD47 may allow early diagnosis of severe COVID-19

A new study reports the potential of the cell surface marker, CD47, as a biomarker for hyperinflammation, a characteristic feature of severe COVID-19. ....

Liji Thomas , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Public Health , Pulmonary Hypertension , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Signaling Pathway , கொரோனா வைரஸ் , நீரிழிவு நோய் , உடல் பருமன் , சர்வதேச பரவல் , பொது ஆரோக்கியம் , நுரையீரல் உயர் இரத்த அழுத்தம் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , சமிக்ஞை நடைபாதை ,

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19. ....

Lakshmi Supriya , Drug Administration , Phd Mar , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Line , Corona Virus , In Vitro , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , லட்சுமி சுப்ரியா , ஃப்ட் மார் , செல் வரி , கொரோனா வைரஸ் , இல் விட்ரோ , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Scientists reprogram a common bacterium to make designer sugar-based drug

Scientists reprogram a common bacterium to make designer sugar-based drug
Envisioning an animal-free drug supply, scientists have -; for the first time -; reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published today in
Nature Communications, the researchers modified
E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.
Genetically engineered
E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules -; called sulfated glycosaminoglycans -;that are often used as drugs and nutraceuticals.. ....

Jonathan Dordick , Deepak Vashishth , Robert Linhardt , Mattheos Koffas , Emily Henderson , Nature Communications , Rensselaer Polytechnic Institute , Rensselaer Polytechnic , E Coli , தீபக் வஷிஷ்ட் , ராபர்ட் லின்ஹார்ட் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , ரென்சீலர் பாலிடெக்நிக் , ஏ கோலி ,