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Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis


Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis
Insilico Medicine has demonstrated a breakthrough in Artificial Intelligence ( AI ) and drug discovery linking together generative chemistry and biology for the first time to discover a novel preclinical candidate addressing idiopathic pulmonary fibrosis ( IPF ) and be validated with multiple human cell and animal model experiments.
Often found implicated in a wide range of diseases and multiple organs such as lung, liver and kidney, IPF addresses a very broad medical need that affects hundreds of thousands of individuals worldwide.
The pinnacle of the deep learning revolution can be pinged to 2014 when deep learning systems accelerated by NVIDIA GPUs and AI software started outperforming humans in image recognition and generative adversarial networks were invented. It is also the year when we started the company. In 2016 we demonstrated that a deep learning system can ....

Feng Ren , Alex Zhavoronkov , Charles Cantor , Emily Henderson , Jensen Huang , Tudor Oprea , University Of Toronto , Translational Informatics Division , University Of New Mexico , Founder Of Retrotope Inc , Professor Emeritus At Boston University , Founder Of Sequenom Inc , Artificial Intelligence , Chief Science , Insilico Medicine , Structure Based Drug Design , Ligand Based Drug Design , New Mexico , Professor Emeritus , Boston University , Science Advisory Board , Sequenom Inc , Computer Science , Animal Model , Clinical Trial , Deep Learning ,

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms


Glycan switch may explain why SARS-CoV-2 causes such variable symptoms
Researchers in Portugal have provided evidence that might explain why infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes mild or even asymptomatic illness in some individuals, but severe coronavirus disease 2019 (COVID-19) in others.
Salome Pinho from the University of Porto and colleagues showed that circulating T cells exhibit a specific “glycan switch” following infection with SARS-CoV-2 and that this switch is more pronounced in asymptomatic versus symptomatic individuals.
The researchers say this change in the T cell glycosylation profile appears to be triggered by a serum inflammatory factor, the identification of which could lead to a potential new biomarker and therapeutic target. ....

Salome Pinho , Sally Robertson , University Of Porto , Dendritic Cell Specific Intercellular , Grabbing Non Integrin , Image Credit , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Dendritic Cell , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , சலோம் பின்ஹோ , சாலி ராபர்ட்சன் , பல்கலைக்கழகம் ஆஃப் போர்டோ , படம் கடன் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity


Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity
An allosteric center or site is one where a molecule other than the substrate to the protein can bind, altering the conformation of the protein. A paper recently uploaded to the preprint server
bioRxiv by researchers at Chapman University in California (Feb 22nd, 2021) utilized computational methods to screen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants for affinity with the angiotensin-converting enzyme 2 (ACE2) receptor and monoclonal antibodies REG10987 and REG10933. The analysis allowed the group to identify allosteric centers that mediate long-range communication in the protein. The group suggests that it is these centers that allow the spike protein of SARS-CoV-2 to act in such a versatile manner, modulating the response to antibodies while conserving ACE2 affinity. ....

United States , South Africa , Chapman University , United Kingdom , South African , Michael Greenwood , Comparative Perturbation Based Modeling , Protein Binding , Host Receptor , Neutralizing Antibodies , Global Circulating , Image Credit , Sars Cov 2 , Spike Protein , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , சாப்மேன் பல்கலைக்கழகம் , ஒன்றுபட்டது கிஂக்டம் , மைக்கேல் கிரீன்வுட் , ப்ரோடீந் பிணைப்பு , தொகுப்பாளர் ஏற்பி ,

COVID-19 may alter host proteins to cause autoimmunity


COVID-19 may alter host proteins to cause autoimmunity
To better understand the transient and chronic autoimmune symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, researchers from Memorial Sloan Kettering Cancer Center, Guizhou Medical University, and biotech company Curandis embarked on an endeavor to establish a comprehensive autoantigenome for COVID19.
In a previous study, the team identified a repertoire of autoantigens (autoAgs) from human fetal lung fibroblast HFL1 cells strongly tied to neurological and diverse autoimmune symptoms COVID19.
In the current study, they aimed to identify more autoAgs from A549 cells, which are human lung epithelium-like cells, derived from adenocarcinoma cells used to model SARS-CoV-2 infection. ....

Liji Thomas , Guizhou Medical University , Memorial Sloan Kettering Cancer Center , Antiphospholipid Syndrome , Binding Affinity , Cell Signaling , Corona Virus , Coronavirus Disease Covid 19 , Immune Response , Protein Expression , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , நினைவகம் ஸ்லோன் கெட்டரிங் புற்றுநோய் மையம் , பிணைப்பு இன உறவு , செல் சமிக்ஞை , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , ப்ரோடீந் வெளிப்பாடு , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,