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Researchers synthesize peptoids at Berkeley Lab to combat viruses


Researchers synthesize peptoids at Berkeley Lab to combat viruses
Researchers Annelise E. Barron and Gill Diamond discovered peptoids, biomimetic molecules that could be used to fight viruses, such as SARS-CoV-2.
A team of researchers discovered that molecules called peptoids, which they synthesized at the Lawrence Berkeley National Lab, or the Berkeley Lab, can be used to fight a variety of viruses.
Peptoids are biomimetic molecules, meaning that they mimic the body’s natural proteins but are themselves not natural, according to Annelise E. Barron, researcher and Stanford University bioengineering professor. Barron called the Molecular Foundry, a research facility of the Berkeley Lab where the peptoids were synthesized, “a really fantastic facility.” ....

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New Research Findings Published in Pharmaceuticals Identify Novel Peptoids with Potent Antiviral Act


in vitro antiviral activity against both HSV-1 and SARS-CoV-2.
As outlined in the paper’s abstract, viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few drugs that treat viral infections effectively, and no vaccine to prevent HSV-1 infections exists.
“There’s a huge need for new antiviral agents,” said Dr. Diamond, “and whereas new vaccines are now available for SARS-CoV-2, treatments can help those who become infected and develop Covid-19 illness. This paper constitutes the first report of biomimetic antiviral peptoids stable mimics of natural antiviral peptides that effectively inactivate two different enveloped viruses, utilizing a mechanism of action similar to that of natural innate immunity. Recurrent HSV-1 infections affect around 177M adult Americans; and of course, SARS-CoV-2 affects us all.” ....

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