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New map reveals genes that control the skeleton


Credit: Garvan Institute of Medical Research
Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton s master regulator cells, known as osteocytes.
The study published today in
Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones.
This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component, says the study s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapies on the skeleton. ....

New York , United States , United Kingdom , City Of , Janice Gibson , Scott Youlten , Peter Croucher , King College London , Nature Communications , Garvan Institute , Bone Biology Lab , York Genome Center , Wellcome Trust Strategic Award , University Of Queensland , Head Of The Bone Biology Lab , Garvan Institute Of Medical Research , Imperial College London , Wellcome Trust Sanger Institute , Ernest Heine Family Foundation , Institute Of Translational Genomics , Mcgill University , Medical Research , Research Officer , Bone Biology , Professor Peter Croucher , Deputy Director ,

Small cell lung cancer: Scientists identify two new approaches for therapy


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Credit: Christina Bebber
Using samples of small cell lung tumours, a research team led by biologist Dr Silvia von Karstedt has discovered two new ways to induce tumour cell death. One of two subsets of tumour cells can be targeted by activating ferroptosis: iron-dependent cell death caused by oxidative stress. In the second subtype, oxidative stress - and hence cell death - can also be induced in a different way. Both types of cell death must be triggered simultaneously by drugs to kill the majority of the tumour mass. The results of the study have been published in
Nature Communications. ....

Christina Bebber , Nature Communications , University Of Cologne , Department Of Translational Genomics , Aging Research , Translational Genomics , Molecular Medicine Cologne , கிறிஸ்டினா பேபிபேர் , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் கொலோன் , துறை ஆஃப் மொழிபெயர்ப்பு மரபியல் , மொழிபெயர்ப்பு மரபியல் , மூலக்கூறு மருந்து கொலோன் ,