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Potential Blood Biomarker for TBI, and Mechanistic Link with Alzheimer's Disease Identified

Potential Blood Biomarker for TBI, and Mechanistic Link with Alzheimerâs Disease Identified
April 15, 2021
Source: Moussa81/Getty Images
Scientists headed by a team at the Harrington Discovery Institute have discovered a potential new approach to preventing brain nerve cells from deteriorating after brain injury. The teamâs work, reported in
Cell, demonstrated that traumatic brain injury (TBI) induces acetylation of the tau protein at sites that are also acetylated in human Alzheimerâs disease (AD), and revealed a potential mechanistic link between TBI and AD. The studies in addition indicated that blood levels of acetylated tau (ac-tau) could represent a potential biomarker for TBI. Strikingly, the researchers found that two FDA-approved NSAID (nonsteroidal anti-inflammatory drug) medicines, salsalate and diflunisal, were potently neuroprotective after TBI in mice, while an analysis of human records indicated that use of either drug for other indi ....

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Researchers discover a new way to prevent brain nerve cells from deteriorating after injury

Researchers discover a new way to prevent brain nerve cells from deteriorating after injury
Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with some form of chronic impairment after suffering a TBI. Even in a mild form, TBI can lead to lifelong nerve cell deterioration associated with a wide array of neuropsychiatric conditions. Tragically, there are no medicines to protect nerve cells after injury. Behind aging and genetics, TBI is the third leading cause of Alzheimer s disease (AD), yet the link between these two conditions is not understood. ....

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Researchers discover new way to monitor & prevent nerve cell deterioration after TBI

Researchers discover new way to monitor & prevent nerve cell deterioration after TBI
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , Kyoo Shin , Roberta Bonomo , Andrewa Pieper , Case Western Reserve School Of Medicine , Brockman Foundation , Allen Initiative In Brain Health , Va Geriatric Research , Harrington Discovery Institute , Neuropathology Core Of Northwestern University , Neurosurgery Of Mcgovern Medical School , Neurotherapeutics Center At University Hospitals , University Hospitals , Morley Mather Chair , Translational Therapeutics Core , Cleveland Alzheimer , Disease Research Center , Clinical Care , Min Kyoo Shin , Associate Chief , Ohio Healthcare System , Case Western Reserve School , Case Western Reserve , Cleveland Clinic , Allen Initiative , Brain Health ,

Protecting the Developing Brain from Prenatal Stress

Protecting the Developing Brain from Prenatal Stress
Source: Justin Paget/Getty Images
February 1, 2021
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Researchers from the University of Iowa (UI) and University Hospitals Cleveland Medical Center report that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy. The team published its study “Maternal P7C3-A20 Treatment Protects Offspring from Neuropsychiatric Sequelae of Prenatal Stress” in
Antioxidants & Redox Signaling.
Working in a mouse model, Rachel Schroeder, a student in the UI Interdisciplinary Graduate Program in Neuroscience, drew a connection between the work of her two mentors, Hanna Stevens, MD, PhD, UI associate professor of psychiatry and Ida P. Haller Chair of Child and Adolescent Psychiatry, and Andrew A. Pieper, MD, PhD, a former UI faculty member. Pieper is now Morley-Mather Chair of Neuropsychiatry at Case Western Reserve University and Investigator and ....

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Scientists find strategy to protect developing brain from prenatal stress in mice

Scientists find strategy to protect developing brain from prenatal stress in mice
ANI |
Updated: Jan 29, 2021 16:05 IST
Washington [US], January 29 (ANI): New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy.
Working in a mouse model, Rachel Schroeder, a student in the UI Interdisciplinary Graduate Program in Neuroscience, drew a connection between the work of her two mentors, Hanna Stevens, MD, PhD, UI associate professor of psychiatry and Ida P. Haller Chair of Child and Adolescent Psychiatry, and Andrew A. Pieper, MD, PhD, a former UI faculty member, now Morley-Mather Chair of Neuropsychiatry at Case Western Reserve University and Investigator and Director of the Neurotherapeutics Center at the Harrington Discovery Institute, University Hospitals C ....

United States , Andrewa Pieper , Shanna Stevens , Idap Haller , Rachel Schroeder , Louis Stokes Va Medical Center , Ui Interdisciplinary Graduate Program In Neuroscience , Harrington Discovery Institute , Neuropsychiatry At Case Western Reserve University , University Of Iowa , University Hospitals Cleveland Medical Center , Neurotherapeutics Center , Graduate Program , Adolescent Psychiatry , Morley Mather Chair , Case Western Reserve University , University Hospitals Cleveland Medical , Louis Stokes , ஒன்றுபட்டது மாநிலங்களில் , ஹன்னா ஸ்டீவன்ஸ் , ரேச்சல் ஸ்க்ரோடர் , லூயிஸ் ஸ்டோக்ஸ் வா மருத்துவ மையம் , உய் இடைநிலை பட்டதாரி ப்ரோக்ர்யாம் இல் நரம்பியல் , ஹாரிங்டன் கண்டுபிடிப்பு நிறுவனம் , நரம்பியல் உளவியல் இல் வழக்கு மேற்கு இருப்பு பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் ஐயுவா ,