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Potential Blood Biomarker for TBI, and Mechanistic Link with Alzheimer's Disease Identified


Potential Blood Biomarker for TBI, and Mechanistic Link with Alzheimer’s Disease Identified
April 15, 2021
Source: Moussa81/Getty Images
Scientists headed by a team at the Harrington Discovery Institute have discovered a potential new approach to preventing brain nerve cells from deteriorating after brain injury. The team’s work, reported in
Cell, demonstrated that traumatic brain injury (TBI) induces acetylation of the tau protein at sites that are also acetylated in human Alzheimer’s disease (AD), and revealed a potential mechanistic link between TBI and AD. The studies in addition indicated that blood levels of acetylated tau (ac-tau) could represent a potential biomarker for TBI. Strikingly, the researchers found that two FDA-approved NSAID (nonsteroidal anti-inflammatory drug) medicines, salsalate and diflunisal, were potently neuroprotective after TBI in mice, while an analysis of human records indicated that use of either drug for other indi ....

United States , Kyoo Shin , Roberta Bonomo , Andrewa Pieper , Case Western Reserve School Of Medicine , Harrington Discovery Institute , Neurotherapeutics Center At University Hospitals , Va Geriatric Research , Investigator Andrew , University Hospitals , Morley Mather Chair , Translational Therapeutics Core , Cleveland Alzheimer , Disease Research Center , Clinical Care , Min Kyoo Shin , Associate Chief , Ohio Healthcare System , Case Western Reserve School , ஒன்றுபட்டது மாநிலங்களில் , ரோபர்ட்டா போனமோ , வழக்கு மேற்கு இருப்பு பள்ளி ஆஃப் மருந்து , ஹாரிங்டன் கண்டுபிடிப்பு நிறுவனம் , புலனாய்வாளர் ஆண்ட்ரூ , பல்கலைக்கழகம் மருத்துவமனைகள் , மோர்லி ம்யாதர் நாற்காலி ,