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Bold Therapeutics Secures Funding to Prepare BOLD-100 for COVID-19 Clinical Trials


COVID-19 cases continue to escalate worldwide
The original announcement by the National Research Council of Canada is available at bit.ly/2JRa4fQ.
BOLD-100 is a first-in-class ruthenium-based small molecule drug which selectively inhibits stress-induced upregulation of the chaperone protein GRP78. Currently, the investigational treatment is in a Phase 1b clinical trial in gastrointestinal cancer. In cancer, GRP78 plays a critical role in resistance, survival and proliferation, whereas in viral infections, GRP78 plays a critical role in host recognition, viral entry and viral replication. Preclinical studies have repeatedly demonstrated BOLD-100 has a robust antiviral response against COVID-19.
We are thankful to have this support from NRC IRAP to continue developing BOLD-100 as an antiviral stated Mark Bazett, PhD, Director of Preclinical Development of Bold Therapeutics. We look forward to completing the next required set of nonclinical and manufacturing studies so ....

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