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Scientists seek insight into Parkinson's, addiction by tracking gene expression in the brain | MIT News


Caption:
Myriam Heiman (left) and Alan Jasanoff have received grants to screen for genes that could help brain cells withstand Parkinson’s disease and to map how gene expression changes in the brain in response to drugs of abuse.
Caption:
An immunofluorescence image taken in a brain region called the substantia nigra (SN) highlights tyrosine hydroxylase, a protein expressed by dopamine neurons. This type of neuron in the SN is especially vulnerable to neurodegeneration in Parkinson s disease.
Credits:
Image: Preston Ge/Heiman Lab
Caption:
Cerebral vasculature in mouse brain. The Jasanoff lab hopes to develop a method for mapping gene expression in the brain with related labeling characteristics. ....

Myriam Heiman , Alan Jasanoff , Broad Institute , Department Of Brain , Mathers Foundation , Mcgovern Institute For Brain Research , Leilay Mathers Foundation , Cognitive Sciences , Picower Institute For , Picower Institute , Mcgovern Institute , Brain Research , Neurobiological Engineering , Picower Institute For Learning And Memory , Broad Institute Of Mit And Harvard , Mit Faculty , Parkinsons Disease , Drug Addiction , Gene Expression , Huntington Amp 039s Disease , மியிரியம் ஹெய்மன் , பரந்த நிறுவனம் , துறை ஆஃப் மூளை , ம்யாதர்ஸ் அடித்தளம் , மகவர்ந் நிறுவனம் க்கு மூளை ஆராய்ச்சி , அறிவாற்றல் அறிவியல் ,

Study shows endothelial cell targeting could help fight Covid-19 symptoms


Credit: Stony Brook University
The News in Brief:
SARS-CoV-2 likely activates endothelial cell responses in patients which contributes to serious lung symptoms, vascular obstruction and respiratory distress with Covid-19.
A study shows that endothelial cells which line capillaries lack ACE2 receptors for SARS-CoV-2 attachment and suggests that SARS-CoV-2 indirectly activates endothelial cell linked disease mechanisms that direct coagulation and inflammation associated with severe Covid-19 disease.
As a result, endothelial cell activation and SARS-CoV-2 induced endothelial cell responses may be potential therapeutic targets to help resolve Covid-19 disease.
STONY BROOK, NY, December 14, 2020 - For Covid-19 patients with serious lung disease, targeting endothelial cells -cells that comprise the blood vessel wall which regulate oxygen exchange between airways and the bloodstream- may be a novel approach restoring normal lung function. This hypothesis stems from ....

United States , Erich Mackow , American Society For Microbiology , Mathers Foundation , Stony Brook University , Department Of Microbiology , Renaissance School , American Society , National Institutes , National Institute , Infectious Diseases , ஒன்றுபட்டது மாநிலங்களில் , அமெரிக்கன் சமூகம் க்கு நுண்ணுயிரியல் , ம்யாதர்ஸ் அடித்தளம் , ஸ்டோனி சிற்றாறு பல்கலைக்கழகம் , துறை ஆஃப் நுண்ணுயிரியல் , மறுமலர்ச்சி பள்ளி , அமெரிக்கன் சமூகம் , தேசிய நிறுவனங்கள் , தேசிய நிறுவனம் , தொற்று நோய்கள் ,