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E-Mail DALLAS, March 11, 2021 A long-term look at Medicare patients shows that Black patients who have an ischemic stroke (blocked blood flow to the brain) die at a higher rate than white patients, even after accounting for preexisting health conditions, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. “So much of what we know is limited to the early or acute phase the first two weeks after a stroke,” said lead study author Judith H. Lichtman, Ph.D., M.P.H., professor and chair of the department of epidemiology at the Yale School of Public Health in New Haven, Connecticut. “When you have a stroke, it’s not just about the acute event, it’s about the early recovery period to secondary prevention visits that affect your long-term ....
Could transforming alpha cells into beta cells treat diabetes? Written by James Kingsland on March 4, 2021 Fact checked by Rita Ponce, Ph.D. New research in mice suggests a novel way to treat both forms of diabetes. 1130945222 Tom Werner/Getty Images Scientists have used synthetic antibodies to block cell receptors in the liver that normally bind to glucagon, a hormone involved in increasing the amount of glucose in the blood. The antibodies restored normal blood glucose levels in three different mouse models of diabetes. The treatment partly worked by transforming alpha cells in the pancreas into insulin-producing beta cells. The researchers believe that the same approach could treat type 1 and type 2 diabetes in people. ....
Modifying Alpha Cells into Beta Cells Helps Treat Diabetes by Angela Mohan on March 2, 2021 at 12:29 PM PNAS. More than 34 million Americans have diabetes, a disease characterized by a loss of beta cells in the pancreas. Beta cells produce insulin, a hormone necessary for cells to absorb and use glucose, a type of sugar that circulates in the blood and serves as cellular fuel. In Type 2 diabetes, the body s tissues develop insulin resistance, prompting beta cells to die from exhaustion from secreting excess insulin to allow cells to take in glucose. In Type 1 diabetes, which affects about 10 percent of the diabetic population, beta cells die from an autoimmune attack. Both kinds of diabetes lead to severely elevated blood sugar levels that eventually cause a host of possible complications, including loss of limbs and eyesight, kidney damage, diabetic coma, and death. ....
Study could offer a new way to treat Type 1 and Type 2 diabetes Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people. More than 34 million Americans have diabetes, a disease characterized by a loss of beta cells in the pancreas. Beta cells produce insulin, a hormone necessary for cells to absorb and use glucose, a type of sugar that circulates in the blood and serves as cellular fuel. ....
E-Mail IMAGE: At left is a healthy islet with many insulin-producing cells (green) and few glucagon-producing cells (red). At right, this situation is altered in a diabetic islet with a heavy preponderance. view more Credit: UT Southwestern Medical Center Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people. More than 34 million Americans have diabetes, a disease characterized by a loss of beta cells in the pancreas. Beta cells produce insulin, a hormone necessary for cells to absorb and use glucose, a type of sugar that circulates in the blood and serves as cellular fuel. ....