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New insight into when CAR T is effective against childhood leukaemia


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Scientists and clinicians at UCL and Great Ormond Street Hospital (GOSH) studying the effectiveness of CAR T-cell therapies in children with leukaemia, have discovered a small sub-set of T-cells that are likely to play a key role in whether the treatment is successful.
Researchers say stem cell memory T-cells appear critical in both destroying the cancer at the outset and for long term immune surveillance and exploiting this quality could improve the design and performance of CAR T therapies.
Explaining the study, published in
Nature Cancer, lead author Dr Luca Biasco (UCL Great Ormond Street Institute of Child Health), said: During clinical trials we have seen some very encouraging results in young patients with leukaemia, however it s still not clear why CAR T-cells continue to be present in the long-term for some patients, stopping the cancer from returning, while others remain at a high risk of relapse. ....

City Of , United Kingdom , Rachael Hough , Adrianj Thrasher , Persis Amrolia , Andre Lopes , Sara Ghorashian , Bilyana Popova , Aleks Guvenel , Rowan Walker , Luca Biasco , Rachel Richardson , Mark Greaves , Natalia Izotova , Robert Wynn , Persisj Amrolia , Cancer Institute , National Institute For Health Research , London Global University , Biomedical Research Centre , Institute Of Child Health , Wellcome Trust , Great Ormond Street Hospital , Nature Cancer , Ormond Street Institute , Child Health ,

Celebrating Mother's Day at Lake Tahoe | TahoeDailyTribune.com


mjacobson@tahoedailytribune.com
Residents and business owners of the Lake Tahoe Basin are preparing for Mother’s Day on Sunday, May 9, after missing out on activities last year due to COVID-19, although florists were able to reopen just in time for that weekend.
Restaurants are opening their doors to patrons, offering bountiful brunches and quality family time.
On the South Shore, Riva Grill will be hosting their Mother’s Day Brunch from 10 a.m. to 2 p.m. Reservations filled up quickly after the restaurant released their a la carte menu, featuring meals such as a seafood platter or biscuits and gravy. ....

Julia Castillo , Rachel Richardson , Lake Tahoe Basin , South Shore , Riva Grill , Day Brunch , Cocktail Corner , Ritz Carlton Marketing Coordinator Rachel , ஜூலியா காஸ்டிலோ , ரேச்சல் ரிச்சர்ட்சன் , ஏரி தஹோ பேசின் , தெற்கு கரை , ரீவ கிரில் , நாள் புருன்சிற்காக , காக்டெய்ல் மூலையில் ,