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How SARS-CoV-2 mutates to escape antibody binding


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IMAGE: Multiple antibodies (green and red) bind SARS-CoV-2 spike protein within cells (blue) when there are no deletions (LEFT). Spike protein deletions stop neutralizing antibody from binding (absence of green).
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Credit: Kevin McCarthy and Paul Duprex
PITTSBURGH, Feb. 3, 2020 - In a recurring pattern of evolution, SARS-CoV-2 evades immune responses by selectively deleting small bits of its genetic sequence, according to new research from the University of Pittsburgh School of Medicine.
Since these deletions happen in a part of the sequence that encodes for the shape of the spike protein, the formerly neutralizing antibody can t grab hold of the virus, the researchers report today in ....

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