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When cancer cells "put all their eggs in one basket"


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Normal cells usually have multiple solutions for fixing problems. For example, when DNA becomes damaged, healthy white blood cells can use several different strategies to make repairs. But cancer cells may “put all their eggs in one basket,” getting rid of all backup plans and depending on just one pathway to mend their DNA.
Cold Spring Harbor Laboratory (CSHL) Professor Christopher Vakoc focuses on probing cancers to figure out if they have any unique dependencies. His lab was surprised to discover that a single DNA repair method remained in acute myeloid leukaemia (AML), aggressive cancer that originates in the bone marrow. They discovered that if they shut down that pathway in cells grown in the laboratory, they could kill the cancer cells while leaving normal cells unharmed. ....

Christopher Vakoc , Cold Spring Harbor Laboratory , Spring Harbor Laboratory , குளிர் வசந்த துறைமுகம் ஆய்வகம் , வசந்த துறைமுகம் ஆய்வகம் ,