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Role of sleep-related brain activity in clearing toxic proteins and preventing Alzheimer's disease

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IMAGE: The global brain signal in Alzheimer s disease patients is associated with weaker cerebrospinal fluid flow as compared with healthy controls
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Credit: Feng Han and Xiao Liu @ The Pennsylvania State University
Evidence of sleep-dependent low-frequency (PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients.
The development of Alzheimer s disease is believed to be driven by the buildup of the toxic proteins amyloid-β and tau in the brain. The brain s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cer ....

University Of Southern California , United States , South Korea , Xiao Liu , Eli Lilly , Michael Weiner , Foundation For The National Institutes Of Health , Department Of Defense , Neurorx Research , Meso Scale Diagnostics , National Institute Of Biomedical Imaging , Merck Co Inc , Pfizer Inc , Laboratory For Neuro Imaging , York University , Roche Ltd , Elan Pharmaceuticals Inc , Transition Therapeutics , Alzheimer Disease Neuroimaging Initiative , Eisai Inc , Pennsylvania State University , Boston University , Canadian Institutes Of Health Research , National Institutes Of Health Grant , Johnson Pharmaceutical Research Development , Northern California Institute For Research ,

To Keep a Sharp Mind, Start Thinking of Heart Health in Your 20s

To Keep a Sharp Mind, Start Thinking of Heart Health in Your 20s
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United States , San Francisco , Eric Vittinghoff , Adina Zeki Al Hazzouri , Kristine Yaffe , Eli Lilly , Karen Matthews , Tina Hoang , San Francisco Va Medical Center , Centers For Disease , Johns Hopkins University , University Of California , Northern California Institute For Research , National Institutes Of Health , National Institute On , Global Council On Brain Health , Columbia University , Artery Risk Development In Young Adults , University Of Pittsburgh , Cardiovascular Health Study , Weill Institute For Neurosciences , Promising Modifiable Risk , Coronary Artery Risk Development , Young Adults , Multi Ethnic Study , Body Composition ,

Data shows strain on ICU capacity leads to more deaths during COVID-19 pandemic

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VIDEO: Research from the U.S. Department of Veterans Affairs, Regenstrief Institute and Indiana University School of Medicine, published in JAMA Network Open, shows that people treated in the ICU for COVID-19.
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Credit: Regenstrief Institute
The COVID-19 pandemic is straining health systems across the country, especially intensive care units. New research from the U.S. Department of Veterans Affairs, Regenstrief Institute and Indiana University School of Medicine shows that people treated in the ICU for COVID-19 are twice as likely to die when the ICU capacity is strained by the number of COVID-19 patients.
These results demonstrate that patients with COVID-19 are more likely to die if they are admitted to an ICU during times with peak COVID-19 caseload, said Dawn Bravata, M.D., first author of the study. We know that strain on hospital capacity has been associated with increased mortality under normal circumstances. This stud ....

Indiana University , United States , Purdue University , San Francisco Veterans Affairs Medical Center , San Francisco , Jennifer Myers , Alan Zillich , Greg Arling , Ying Zhang , Sam Regenstrief , Samuel Leonard , Anthony Perkins , Charles Austin , Laura Myers , Ali Sexon , Rajiv Agarwal , Lindsey Reese , Salomeh Keyhani , Andrew Dysangco , Regenstrief Institute , University Of California , Indiana University School Of Medicine , University Of Nebraska Medical Center , Northern California Institute For Research , Health Information , College Of Public Health ,