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Scientists discover gene signature for plaque-eating microglia in Alzheimer's Disease


Alzheimer’s Disease is the most common form of dementia and is characterised by the build-up of amyloid plaques in the brain. Microglia, the immune sentinels of the brain, are not only responsible for eliminating foreign invaders, but also maintaining brain homeostasis by clearing toxic waste such as the amyloid plaques.
However, the role of microglia in Alzheimer’s Disease and its relationship to amyloid plaque accumulation remain unclear. Now, a team of scientists from Duke-NUS Medical School and Monash University have found the gene expression signatures underlying microglia associated with amyloid plaque phagocytosis – i.e. the engulfing of deposits of the amyloid beta (Aβ) protein in the brain. The findings, reported in the journal  ....

Josem Polo , Enrico Petretto , Metabolic Disorders Programme , Nature Communications , Monash University , Monash Biomedicine Discovery Institute , Nature Neuroscience , Associate Professor Enrico Petretto , Professor Jose , Assoc Prof Petretto , Gabriel Chew , வளர்சிதை மாற்ற கோளாறுகள் ப்ரோக்ராம் , இயற்கை தகவல்தொடர்புகள் , மோனாஷ் பல்கலைக்கழகம் , இயற்கை நரம்பியல் , ப்ரொஃபெஸர் ஜோசே , கேப்ரியல் மெல் ,

Singapore finds molecule for dual protection against vascular inflammation


Singapore finds molecule for dual protection against vascular inflammation
Singapore finds molecule for dual protection against vascular inflammation
23 April 2021 | News
Image credit- shutterstock.com
A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A STAR) in Singapore has discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood vessel and immunity.
The study, published in the journal 
Nature Communications, revealed how one gene encoded two molecules that provide two-pronged protection following viral infection.
“In this study, we aimed to identify new targets to combat inflammation in the lining of blood vessels. Specifically, we wanted to target small naturally-produced peptides that have not been studied before,” explained Assistant Professor Lena Ho, from the Cardiovascular and Metabolic Disorders Progra ....

Owen Rackham , Agency For Science , Nature Communications , Senior Research Fellow Dr Cheryl Lee , Metabolic Disorders Programme At , Metabolic Disorders Programme , Associate Professor Ashley St John , Assistant Professor Owen Rackham , Senior Research Fellow Dr Cheryl , Assoc Prof St John , ஓவந் ராக்ஹாம் , இயற்கை தகவல்தொடர்புகள் , வளர்சிதை மாற்ற கோளாறுகள் ப்ரோக்ராம் இல் , வளர்சிதை மாற்ற கோளாறுகள் ப்ரோக்ராம் , இணை ப்ரொஃபெஸர் ஆஷ்லே ஸ்டம்ப் ஜான் , உதவியாளர் ப்ரொஃபெஸர் ஓவந் ராக்ஹாம் ,