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Treating the 'root' cause of baldness with a dissolvable microneedle patch

Treating the 'root' cause of baldness with a dissolvable microneedle patch
acs.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from acs.org Daily Mail and Mail on Sunday newspapers.

Fangyuan Li , Jianqing Gao , National Natural Science Foundation Of China , Key Research , Zhejiang Provincial Natural Science Foundation Of China , Development Program Of Zhejiang Province , Research Funds For The Central Universities , National Key Rd Program Of China , Belt International Cooperation , Talents Program Of Zhejiang Province , Ten Thousand Talents Program , Zhejiang Province , National Key Rd Program , National Natural Science Foundation , One Belt , One Road International Cooperation Project , Development Program , Fundamental Research Funds , Central Universities , Zhejiang Provincial Natural Science Foundation , தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனா , விசை ஆராய்ச்சி , ஜெஜியாங் மாகாண இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனா , ஆராய்ச்சி நிதி க்கு தி மைய பல்கலைக்கழகங்கள் , தேசிய விசை ர்ட் ப்ரோக்ர்யாம் ஆஃப் சீனா , பத்து ஆயிரம் திறமைகள் ப்ரோக்ர்யாம் ,

Frontiers | A Novel Probable Pathogenic PSEN2 Mutation p.Phe369Ser Associated With Early-Onset Alzheimer's Disease in a Chinese Han Family: A Case Report


Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
The pathogenesis of Alzheimer s disease is complex, and early-onset Alzheimer s disease (EOAD) is mostly influenced by genetic factors. Presenilin-1, presenilin-2 (PSEN2), and amyloid precursor protein are currently known as the three main causative genes for autosomal dominant EOAD, with the PSEN2 mutation being the rarest. In this study, we reported a 56-year-old Chinese Han proband who presented with prominent progressive amnesia, aphasia, executive function impairment, and depression 5 years ago. The 3-year follow-up showed that the patient experienced progressive brain atrophy displayed on magnetic resonance imaging (MRI) and dramatic cognitive decline assessed by neuropsychological evaluation. This patient was clinically diagnosed as EOAD based on established criteria. A heterozygous variant (NM 000447.2: c.1106T>C) of PSEN2 was identified for the first time in this patient a ....

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