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Candidate Immunotherapy Target Identified for Brain Cancer, Possibly Other Tumors


Candidate Immunotherapy Target Identified for Brain Cancer, Possibly Other Tumors
February 16, 2021
Source: National Cancer Institute; creator Rhoda Baer, photographer
Scientists at Dana-Farber Cancer Institute, Massachusetts General Hospital, and the Broad Institute of MIT and Harvard, reported the discovery of a potential new target for immunotherapy of malignant brain tumors. The team used single-cell RNA sequencing (RNA-seq) to study gene expression and the clonal landscape of tumor-infiltrating T cells across more than 30 patients with diffuse gliomas and glioblastoma. Their work indicated that the immune cell surface receptor, CD161, suppresses the cancer-fighting activity of immune T cells, and is activated by its ligand, CLEC2D, on tumor cells and immune-suppressing cells in the brain. Their studies showed that genetically deleting the KLRB1 that codes for CD161, or using antibodies to block CD161, increased T cell-mediated killing of glioma cells in vitro and ....

Dana Farber Cancer Institute , United States , Kai Wucherpfennig , David Reardon , Rhoda Baer , Aviv Regev , Cancer Immunotherapy Research At Dana Farber , Broad Institute , National Cancer Institute , Scientists At Dana Farber Cancer Institute , Massachusetts General Hospital , Mario Suva , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , ஒன்றுபட்டது மாநிலங்களில் , டேவிட் ரிர்டந் , ரோடா பேர் , புற்றுநோய் நோயெதிர்ப்பு சிகிச்சை ஆராய்ச்சி இல் டானா ஃபார்‌பர் , பரந்த நிறுவனம் , தேசிய புற்றுநோய் நிறுவனம் , விஞ்ஞானிகள் இல் டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , மரியோ சுவா ,

Study finds new evidence of health threat from chemicals in marijuana and tobacco smoke


Credit: Pexels
Scientists at Dana-Farber Cancer Institute and the Centers for Disease Control and Prevention have uncovered new evidence of the potential health risks of chemicals in tobacco and marijuana smoke.
In a study published online today by
EClinicalMedicine, the researchers report that people who smoked only marijuana had several smoke-related toxic chemicals in their blood and urine, but at lower levels than those who smoked both tobacco and marijuana or tobacco only. Two of those chemicals, acrylonitrile and acrylamide, are known to be toxic at high levels. The investigators also found that exposure to acrolein, a chemical produced by the combustion of a variety of materials, increases with tobacco smoking but not marijuana smoking and contributes to cardiovascular disease in tobacco smokers. ....

United States , Stevenm Wolinsky , Benjaminb Gelman , Lanqing Wang , Dana Gabuzda , Hajime Uno , Sukrutha Chettimada , Susan Morgello , Davidr Lorenz , Benjaminc Blount , Vikas Misra , Centers For Disease , National Institute On Drug Abuse , National Cancer Institute , National Institute Of Allergy , National Institutes Of Health , Scientists At Dana Farber Cancer Institute , National Institute Of Mental Health , University Of Texas , Icahn School Of Medicine , Northwestern University , National Institute Of Neurological Disorders , Dana Farber Cancer Institute , Disease Control , Icahn School , National Institutes ,

Smoking marijuana exposes you to low levels of the same toxic chemicals found in tobacco smoke


Smoking marijuana exposes the body to some of the same toxic chemicals released from tobacco, but at lower levels, according to a new study. 
Scientists at Dana-Farber Cancer Institute and the Centers for Disease Control and Prevention looked at the levels of several dangerous chemicals in the blood and urine of 245 volunteers.
Some of the volunteers didn t smoke, some smoked either weed or tobacco and dome smoked a combination of both. 
They found that those who only smoked marijuana still had several smoke-related toxic chemicals in their system - but at lower levels than those who also or only smoked tobacco.  ....

United States , United Kingdom , Dana Gabuzda , Centers For Disease , Us National Toxicology Program , American Cancer Society , Scientists At Dana Farber Cancer Institute , World Health Organisation , Dana Farber Cancer Institute , Disease Control , Toxicology Program , American Cancer , Centers For Disease Control And Prevention Cdc , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , மையங்கள் க்கு நோய் , எங்களுக்கு தேசிய நச்சுயியல் ப்ரோக்ர்யாம் , அமெரிக்கன் புற்றுநோய் சமூகம் , விஞ்ஞானிகள் இல் டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , நோய் கட்டுப்பாடு , நச்சுயியல் ப்ரோக்ர்யாம் , அமெரிக்கன் புற்றுநோய் , மையங்கள் க்கு நோய் கட்டுப்பாடு மற்றும் ப்ரெவெந்ஶந் ஸீடீக் ,

Scientists create ON-OFF switches to control CAR T cell activity


CAR T cells are a breakthrough class of effective but often toxic cancer therapies
To prevent overactivation, switchable CAR T cells were engineered that can be turned on and off with an approved, widely used cancer drug
BOSTON - Scientists at Dana-Farber Cancer Institute and Mass General Cancer Center have created molecular ON-OFF switches to regulate the activity of CAR T cells, a potent form of cell-based immunotherapy that has had dramatic success in treating some advanced cancers, but which pose a significant risk of toxic side effects.
CAR T cells are immune cells genetically modified to recognize and attack tumors cells. Once given, these living drugs proliferate and kill tumor cells over weeks to months, in some cases causing life-threatening inflammatory reactions that are difficult to control. In this way, CAR T cells are unlike more established forms of cancer therapy - chemotherapy or radiotherapy for instance - whose dose can be precisely tuned up or d ....

United States , Dana Farber Cancer Institute , Marcela Maus , Edwardp Evans , Benjamin Ebert , Max Jan , Broad Institute , National Institutes Of Health , Cancer Center , Harvard Medical School , Lymphoma Society , Scientists At Dana Farber Cancer Institute , Howard Hughes Medical Institute , Mass General Cancer Center , Science Translational Medicine , Harvard Medical , Medical Oncology , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , மார்செலா மாயஸ் , பெஞ்சமின் எபர்ட் , அதிகபட்சம் ஜான் , பரந்த நிறுவனம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , புற்றுநோய் மையம் ,