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Alphamab Oncology Presents Phase 2 Clinical Data on KN046 Plus Paclitaxel/Cisplatin for the First-line Treatment of ESCC at ASCO 2021


June 07, 2021
SUZHOU, China, June 7, 2021 /PRNewswire/ Alphamab Oncology (stock code: 9966.HK) announced data from Phase 2 clinical study (KN046-204) of KN046(PD-L1/CTLA-4 bispecific antibody) plus paclitaxel/cisplatin for the first-line treatment of unresectable locally advanced, recurrent or metastatic esophageal squamous cell carcinoma (ESCC) is presented in a poster session at the ASCO 2021 (2021 American Society of Clinical Oncology Annual Meeting).
Esophageal cancer is one of the most common malignant tumors in the world. According to data released by GLOBOCAN 2020, approximately 320,000 new cases occurred in China in 2020, accounting for half of the global new cases, of which esophageal squamous cell carcinoma (ESCC) is the main subtype (90%-95%). The prognosis of esophageal cancer is very poor, with only about 20% overall 5-year survival rate and 3.5% 5-year survival rate for metastatic patients. There is a huge unmet clinical need. KN046-204 is a phase II clinic ....

United States , Hong Kong , Jiangsu Alphamab , Jianming Xu , Johannes Nippgen , American Society Of Clinical Oncology Annual Meeting , Hong Kong Stock Exchange , European Union , National Medical Products Administration , Chinese People Liberation Army , Clinical Oncology Annual Meeting , Gastrointestinal Cancer , Chinese People , Liberation Army General , Liberation Army General Hospital , Chief Medical Officer , Alphamab Oncology , Priority Review , ஒன்றுபட்டது மாநிலங்களில் , ஹாங் காங் , அமெரிக்கன் சமூகம் ஆஃப் மருத்துவ புற்றுநோயியல் ஆண்டு சந்தித்தல் , ஹாங் காங் ஸ்டாக் பரிமாற்றம் , ஐரோப்பிய தொழிற்சங்கம் , சீன மக்கள் விடுதலை இராணுவம் , மருத்துவ புற்றுநோயியல் ஆண்டு சந்தித்தல் , இரைப்பை குடல் புற்றுநோய் ,

New insights on how hospitalized patients develop liver injury from taking different drugs


New insights on how hospitalized patients develop liver injury from taking different drugs
A new study published in the
British Journal of Clinical Pharmacology provides insights on how common hospitalized patients develop liver injury from taking different medications.
When investigators analyzed the records of 156,570 hospitalized patients, they found 499 cases of drug-induced liver injury (DILI), for an incidence of 0.32%. Anti-infective agents, cancer medications, and nonsteroidal anti-inflammatory drugs were the major categories of drugs causing DILI, and the highest incidence was due to voriconazole (an antifungal medication). Patients with high cholesterol, cardiovascular disease, pre-existing liver disease, and prior surgeries faced a higher risk of DILI. ....

United Kingdom , Daihong Guo , Emily Henderson , Chinese People Liberation Army , British Journal , Clinical Pharmacology , Corresponding Author , Chinese People , Liberation Army General Hospital , ஒன்றுபட்டது கிஂக்டம் , எமிலி ஹென்டர்சன் , சீன மக்கள் விடுதலை இராணுவம் , பிரிட்டிஷ் இதழ் , மருத்துவ மருந்தியல் , சீன மக்கள் , விடுதலை இராணுவம் ஜநரல் மருத்துவமனை ,