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Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer's Disease


Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer’s Disease
In animal models, the new compound modulated a key enzyme, reducing or eliminating production of problematic protein fragments; human clinical trials needed
March 02, 2021
 |  Scott LaFee
News release
Amyloid plaques are pathological hallmarks of Alzheimer’s disease (AD) clumps of misfolded proteins that accumulate in the brain, disrupting and killing neurons and resulting in the progressive cognitive impairment that is characteristic of the widespread neurological disorder.
In a new study, published March 2, 2021 in the
Journal of Experimental Medicine (JEM), researchers at University of California San Diego School of Medicine, Massachusetts General Hospital and elsewhere have identified a new drug that could prevent AD by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques. ....

San Diego , United States , New Hampshire , University Of California San Diego , Douglas Galasko , Kevind Rynearson , Brian Spencer , Jazmin Florio , Carlos Arias , Roberta Rissman , Gopal Thinakaran , Yuhuan Xie , Graham Johnson , Jiunnh Lin , Michael Mante , Mariko Sawa , Olga Prikhodko , Rudolph Tanzi , Moorthi Ponnusamy , Yann Becker , Bahar Salehi , Stevenk Duddy , Williamc Mobley , Stevenl Wagner , Phuong Nguyen , Centers For Disease ,

How does your brain process emotions? Answer could help address loneliness epidemic


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IMAGE: Jyoti Mishra, PhD, is the senior author of the study, director of the NEATLabs and assistant professor in the Department of Psychiatry at UC San Diego School of Medicine.
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Credit: UC San Diego Health Sciences
Research over the last decade has shown that loneliness is an important determinant of health. It is associated with considerable physical and mental health risks and increased mortality. Previous studies have also shown that wisdom could serve as a protective factor against loneliness. This inverse relationship between loneliness and wisdom may be based in different brain processes.
In a study published in the March 5, 2021 online edition of ....

San Diego , United States , University Of California San Diego , Dilipv Jeste , Jyoti Mishra , Fahad Alim , Gillian Grennan , Mariam Zafar Khan , Pragathi Priyadharsini Balasubramani , Kellen Lee , Veterans Affairs San Diego Healthcare System , Department Of Psychiatry , Uc San Diego School Of Medicine , Cerebral Cortex , California San Diego School , Diego School , Healthy Aging , Distinguished Professor , Veterans Affairs San Diego Healthcare , Medicine Health , Mental Health , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , ஜையோடீ மிஸ்ரா , பாத் ஆலிம் ,

Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer's Disease

Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer's Disease
scienceblog.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from scienceblog.com Daily Mail and Mail on Sunday newspapers.

San Diego , United States , New Hampshire , University Of California San Diego , Douglas Galasko , Kevind Rynearson , Brian Spencer , Jazmin Florio , Carlos Arias , Roberta Rissman , Gopal Thinakaran , Yuhuan Xie , Graham Johnson , Jiunnh Lin , Michael Mante , Mariko Sawa , Olga Prikhodko , Rudolph Tanzi , Moorthi Ponnusamy , Yann Becker , Bahar Salehi , Stevenk Duddy , Williamc Mobley , Stevenl Wagner , Phuong Nguyen , Centers For Disease ,