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Scar-Forming Cells Switch to Producing New Neurons that Promote Functional Recovery in Mice after Spinal Cord Injury

Scar-Forming Cells Switch to Producing New Neurons that Promote Functional Recovery in Mice after Spinal Cord Injury
genengnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from genengnews.com Daily Mail and Mail on Sunday newspapers.

Chun Li Zhang , Ww Caruth Jr , Indiana University , Cell Stem , Phd However , சுன் லி ஜாங் , வ்வ் கருத் ஜூனியர் , இந்தியானா பல்கலைக்கழகம் , செல் தண்டு ,

Putting a protein into overdrive to heal spinal cord injuries

Credit: UT Southwestern Medical Center
Using genetic engineering, researchers at UT Southwestern and Indiana University have reprogrammed scar-forming cells in mouse spinal cords to create new nerve cells, spurring recovery after spinal cord injury. The findings, published online today in
Cell Stem Cell, could offer hope for the hundreds of thousands of people worldwide who suffer a spinal cord injury each year.
Cells in some body tissues proliferate after injury, replacing dead or damaged cells as part of healing. However, explains study leader Chun-Li Zhang, Ph.D., professor of molecular biology and a W.W. Caruth, Jr. Scholar in Biomedical Research at UTSW, the spinal cord typically does not generate new neurons after injury - a key roadblock to recovery. Because the spinal cord acts as a signal relay between the brain and the rest of the body, he adds, its inability to self-repair permanently halts communication between these two areas, leading to paralysis, loss o ....

Indiana University , United States , Chunhai Chen , Chun Li Zhang , Jianjing Yang , Wei Wu , Yuhua Zou , Ww Caruth Jr , Wenjiao Tai , National Institutes Of Health , Research On Nerve Growth , Kent Waldrep Foundation Center , Welch Foundation , Scholar In Biomedical Research , Xiao Ming Xu At Indiana University , Texas Alzheimer Research , Decherd Foundation , Care Consortium , Cell Stem , Biomedical Research , Lei Wang , Tong Zang , Texas Alzheimer , Basic Research , Nerve Growth , National Institutes ,

Investegate |AstraZeneca PLC Announcements | AstraZeneca PLC: Enhertu approved in the US for gastric cancer

previously treated HER2-positive advanced gastric cancer

AstraZeneca and Daiichi Sankyo Company, Limited (Daiichi Sankyo) s
Enhertu
(trastuzumab deruxtecan) has been approved
in the US for the treatment of adult patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen.

In the US, gastric cancer is most frequently diagnosed in the advanced stage, with only approximately 5% of patients surviving beyond five years.
1,2 Approximately one in five gastric cancers are HER2 positive.
3

The approval by the Food and Drug Administration (FDA) was based on the positive results from the randomised DESTINY-Gastric01 Phase II trial conducted in Japan and South Korea. In the trial, Enhertudemonstrated a statistically significant and clinically meaningful improvement in ....

United States , Baylor University , United Kingdom , South Korea , Dave Fredrickson , Ronan Kelly , Daiichi Sankyo , Ww Caruth Jr , Trastuzumab Deruxtecan , Adrian Kemp , Antoine Yver , Daiichi Sankyo Company , Drug Administration , Charlesa Sammons Cancer Center , Oncology Research , Merck Co Inc , Company On Twitter Astrazeneca , Daiichi Sankyo Enhertu , Investor Relations Team , International Agency For Research On Cancer , Immunology At Baylor University Medical Center , American Cancer Society , Cancer Center , Baylor University Medical Center , Executive Vice President , Oncology Business Unit ,

ADDING MULTIMEDIA — ENHERTU® Approved in the U.S. for the Treatment of Patients with Previously Trea

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18-Jan-2021
ADDING MULTIMEDIA ENHERTU® Approved in the U.S. for the Treatment of Patients with Previously Treated HER2 Positive Advanced Gastric Cancer
First HER2 directed medicine approved for patients with gastric cancer in a decade
TOKYO & MUNICH & BASKING RIDGE, N.J. (BUSINESS WIRE) Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) and AstraZeneca’s
ENHERTU
® (fam-trastuzumab deruxtecan-nxki) has been approved in the U.S. for the treatment of adult patients with locally advanced or metastatic HER2 positive gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen.
In the U.S., gastric cancer is more frequently diagnosed in the advanced stage, with only approximately 5% of patients surviving five years. ....

United States , Baylor University , South Korea , Dave Fredrickson , Ronan Kelly , Masashi Kawase , Daiichi Sankyo , Ww Caruth Jr , Daiichi Sankyo Europe Gmb , Antoine Yver , Daiichi Sankyo Company , American Society Of Clinical Oncology , Daiichi Sankyo Inc , Drug Administration , Clinical Development Program , Charlesa Sammons Cancer Center , Oncology Research , Daiichi Sankyo Co Ltd , European Medicines Agency , Immunology At Baylor University Medical Center , Cancer Center , Baylor University Medical Center , Clinical Oncology , New England Journal , Executive Vice President , Global Head ,

ENHERTU® Approved in the U.S. for the Treatment of Patients With Previously Treated HER2 Positive Advanced Gastric Cancer | Antibodies

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First HER2 directed medicine approved for patients with gastric cancer in a decade
TOKYO, Japan & MUNICH, Germany & BASKING RIDGE, NJ USA I January 15, 2021 I Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) and AstraZeneca’s
ENHERTU
® (fam-trastuzumab deruxtecan-nxki) has been approved in the U.S. for the treatment of adult patients with locally advanced or metastatic HER2 positive gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen.
In the U.S., gastric cancer is more frequently diagnosed in the advanced stage, with only approximately 5% of patients surviving five years.
1,2 Approximately one in five gastric cancers are HER2 positive. ....

Baylor University , United States , South Korea , Dave Fredrickson , Ronan Kelly , Daiichi Sankyo , Ww Caruth Jr , Antoine Yver , National Cancer Institute , American Society Of Clinical Oncology , Drug Administration , I Daiichi Sankyo Company , Clinical Development Program , Charlesa Sammons Cancer Center , Oncology Research , Daiichi Sankyo Group , European Medicines Agency , Daiichi Sankyo Company Ltd , Immunology At Baylor University Medical Center , American Cancer Society , Patients With Previously Treated , Advanced Gastric Cancer , Statesi January , Daiichi Sankyo Company , Cancer Center , Baylor University Medical Center ,