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Across China: Shanghai establishes immune therapy institute to bring advances from lab to clinic - Buz & Tech News


2021-05-05 08:35:20 GMT2021-05-05 16:35:20(Beijing Time) Xinhua English
SHANGHAI, May 5 (Xinhua) Shanghai has accelerated its pace of immunological research to take the lead in boosting China s innovation in the prevention and treatment of immunological diseases.
The newly launched Shanghai Immune Therapy Institute is the latest example of the city s efforts to build world-class immunology research hubs. Established at the Renji Hospital under the Shanghai Jiao Tong University School of Medicine, the institute will focus on three research areas: tumor immunotherapy, chronic inflammatory diseases and transplantation immunology, and infectious diseases and vaccines.
The institute aims to become a frontier research and development center with global talent by 2025, and one of the world s leading institutes in the fields of new drug targets, new mechanisms, antibody-drug development, immunotherapy and other major immune-related diseases by 2035, according to a hos ....

Dong Chen , Shanghai Jiao Tong University School Of Medicine , School Of Medicine , Shanghai Immune Therapy Institute , Chinese Academy Of Sciences , Renji Hospital , Shanghai Jiao Tong University School , Fan Xianqun , Chinese Academy , டாங் சென் , ஷாங்காய் ஜியாவோ நாக்கு பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , பள்ளி ஆஃப் மருந்து , சீன கலைக்கழகம் ஆஃப் அறிவியல் , ரென்ஜி மருத்துவமனை , ஷாங்காய் ஜியாவோ நாக்கு பல்கலைக்கழகம் பள்ளி , சீன கலைக்கழகம் ,

Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation


Cd86), were down-regulated in
Mettl3-deficient cells (Fig. 1G), suggesting that METTL3 has a critical function in controlling the innate immune response of Raw 264.7 macrophages.
To further confirm the biological role of the m
6A modification in macrophages,
Mettl3 conditional KO (CKO) mice were generated by crossing
Mettl3
flox/flox mice with mice expressing Cre recombinase under the control of lysozyme 2 promoter (
Lyzm-Cre). We have documented the loss of both the METTL3 protein and the overall m
6A modification in bone marrow–derived macrophages (BMDMs) from
Mettl3
flox/flox;
Lyzm-Cre mice (fig. S1I). No differences in the frequency of major immune cell populations were observed between ....

United States , Agilent Bioanalyzer , Amersham Hybond , Merck Millipore , Hua Bing Li , Lipofectamine Rnaimax Invitrogen , Shanghai Jiao Tong University School Of Medicine , National Center , National Natural Science Foundation Of China , Q Zou Shanghai Institute Of Immunology , Zai Lab Ltd , Library Prep Human Mouse Rat Illumina , Yale University School Of Medicine , Technology Committee , Ge Healthcare , National Key Rd Program Of China , R Af Department Of Immunobiology , Howard Hughes Medical Institute , Bar Harbor , Animal Care , House Committees , Shanghai Jiao Tong University School , Shanghai Institute , Shanghai Jiao Tong University , Biotechnology Information , Gene Expression Omnibus ,

NMPA Approves Toripalimab in Patients with Locally Advanced or Metastatic Urothelial Carcinoma


Published: Apr 12, 2021
SHANGHAI, China, April 12, 2021 (GLOBE NEWSWIRE) Junshi Biosciences (HKEX: 1877; SSE: 688180), a leading innovation-driven biopharmaceutical company dedicated to the discovery, development and commercialization of novel therapies, announced today that the National Medical Products Administration (NMPA) of China has granted a conditional approval to toripalimab for the treatment of patients with locally advanced or metastatic urothelial carcinoma who failed platinum-containing chemotherapy or progressed within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. This is the third approved indication for toripalimab in China. In December 2018, the NMPA granted a conditional approval to toripalimab for the second-line treatment of unresectable or metastatic melanoma. In February 2021, the NMPA granted a conditional approval to toripalimab for the treatment of patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) afte ....

United States , San Francisco , Huang Yiran , Patricia Keegan , Junshi Biosciences , Guo Jun , Eli Lilly , Institute Of Microbiology Chinese Academy Science , Shanghai Jiao Tong University School Of Medicine , Guidelines Of Chinese Society Clinical Oncology , Ir Team , University Cancer Hospital , Drug Administration , National Reimbursement Drug List , National Medical Products Administration , Pr Team , Chief Medical Officer , Professor Guo Jun , Peking University Cancer Hospital , Professor Huang Yiran , Renji Hospital , Shanghai Jiao Tong University School , Independent Review Committee , Chinese Society , Clinical Oncology , Breakthrough Therapy Designation ,

Medical experts call for better kidney care


Medical experts call for better kidney care
By Zhou Wenting in Shanghai |
chinadaily.com.cn |
Updated: 2021-03-10 11:27
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Leading medical experts call for a higher awareness of chronic kidney diseases, which afflict more than 150 million people in China, ahead of the World Kidney Day on March 11. [Photo by Zhou Wenting/chinadaily.com.cn]
Medical experts have called for a higher awareness of chronic kidney diseases, especially the type that afflicts young and middle-aged people, ahead of World Kidney Day on March 11.
According to World Health Organization figures released in December, kidney diseases have become one of the top 10 causes of death in the world. In China, more than 150 million people suffer from chronic kidney diseases. ....

Wang Niansong , Shanghai Jiao Tong University School Of Medicine , World Health Organization , European Medicines Agency , Drug Administration , World Kidney Day , Renji Hospital Affiliated , Shanghai Jiao Tong University School , Everest Medicines , United State Food , ஷாங்காய் ஜியாவோ நாக்கு பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , உலகம் கிட்நீ நாள் , ரென்ஜி மருத்துவமனை இணைந்த , ஷாங்காய் ஜியாவோ நாக்கு பல்கலைக்கழகம் பள்ளி , எவரெஸ்ட் மருந்துகள் , ஒன்றுபட்டது நிலை உணவு ,