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New findings linking brain immune system to psychosis


Credit: Stefan Zimmerman
New research at Karolinska Institutet in Sweden suggests a link between psychosis and a genetic change that affects the brain s immune system. The study published in
Molecular Psychiatry may impact the development of modern medicines for bipolar disorder or schizophrenia.
Psychosis affects approximately 2-3 per cent of the population and is characterized by a change in the perception of reality, often with elements of hallucinations and paranoid reactions.
Most of the people affected are patients with schizophrenia, but people with bipolar disorder may also experience psychotic symptoms.
The antipsychotics available today often have insufficient efficacy, and for patients, their life situation can be difficult. ....

United States , San Diego , Idaak Nilsson , Alfredo Oliveros , Martin Schalling , Michel Goiny , Anthi Faka , Tomas Hokfelt , Lilly Schwieler , Marie Svedberg , Mikael Landen , Markusk Larsson , Sophie Erhardt , Simone Codeluppi , Anton Schullman , Karolinska Institutet , Carl Sellgren , Magdalenae Kegel , Maximillian Tufvesson Alm , Camillai Svensson , Marquisp Vawter , Sorana Caldwell , Susanb Powell , Carlm Sellgren , Simon Cervenka , Marye Kamenski ,

Rare Mutations May Have Big Impact on Schizophrenia Pathology


Korea Advanced Institute of Science and Technology
Somatic mutations found only in brain cells disrupt synaptic function
Schizophrenia is a neurodevelopmental disorder that disrupts brain activity, producing hallucinations, delusions, and other cognitive disturbances. Researchers have long searched for genetic influences in the disease, but genetic mutations have been identified in only a small fraction fewer than a quarter of sequenced patients. Now a study shows that “somatic” gene mutations in brain cells could account for some of the disease’s neuropathology.
The results of the study, led by Professor Jeong Ho Lee at the Graduate School of Medical Science and Engineering in collaboration with the Stanley Medical Research Institute in the US, appeared in Biological Psychiatry. ....

South Korea , John Krystal , School Of Medical Science , Stanley Medical Research Institute , Korea Advanced Institute Of Science , Professor Jeong Ho Lee , Graduate School , Medical Science , Korea Advanced Institute , Biological Psychiatry , Korea Advanced Institute Of Science And Technology , Agenetic Mutation , Medical Research , Brain Activity , Gene Mutations , தெற்கு கொரியா , ஜான் கிரிஸ்டல் , பள்ளி ஆஃப் மருத்துவ அறிவியல் , ஸ்டான்லி மருத்துவ ஆராய்ச்சி நிறுவனம் , ப்ரொஃபெஸர் ஜியோங் ஹோ லீ , பட்டதாரி பள்ளி , மருத்துவ அறிவியல் , உயிரியல் மனநல மருத்துவம் , ஜெநெடிக் பிறழ்வு , மருத்துவ ஆராய்ச்சி , மூளை நடவடிக்கை ,