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Tumor marker may help overcome endocrine treatment-resistant breast cancer


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Credit: Sanford Burnham Prebys
LA JOLLA, CALIF. - May 19, 2021 - A study led by scientists at Sanford Burnham Prebys Medical Discovery Institute has identified a tumor marker that may be used to predict which breast cancer patients will experience resistance to endocrine therapy. The research offers a new approach to selecting patients for therapy that targets HER2, a protein that promotes the growth of cancer cells, to help avoid disease relapse or progression of endocrine-sensitive disease.
The study was published in the journal
Nature Communications.
Nearly 80% of breast tumors are estrogen receptor (ER)-positive. For decades, these tumors have been treated with anti-estrogen (endocrine) therapies to lower estrogen levels and help slow the cancer s growth. About 20% of breast cancers are also HER2-positive at diagnosis, and these tumors tend to be more aggressive and fast-growing, as HER2 is a receptor that when active, promotes the rapid growth of ....

United States , Nindo Punturi , Shunqiang Li , Vaishnavi Devarakonda , Susang Komen , Svasti Haricharan , Shyamm Kavuri , Ching Hui Chen , Rashi Kalra , Nindob Punturi , Sinem Seker , Sanford Burnham Prebys , Matthewj Ellis , Nature Communications , National Cancer Institute , Program At Sanford Burnham Prebys , Alliance For Clinical Trials In Oncology , National Institutes Of Health , Cancer Center , Sanford Burnham Prebys Medical Discovery Institute , Tina Primeau At Washington University In St , Neozenome Therapeutics Inc , Career Development , Sanford Burnham Prebys Medical Research Institute , Immuno Oncology Program , Aloran Mazumder ,

Best Bets for the Break: A quick guide to online entertainment and virtual experiences


The
La Jolla Light presents this continuing series of online activities to undertake on your computer or tablet during your quarantine quandary.
Lectures & learning
• The UC San Diego economics department presents
“Memory and Financial Decisions” at 8 a.m. Friday, April 16, online. The talk will feature Jessica Wachter, an economics professor at the University of Pennsylvania, sharing some of her findings on how the limitations of human memory may contribute to phenomena such as asset price momentum and financial crises. Free. Register at
• Jewish National Fund-USA in San Diego presents
“Breakfast for Israel” at 10:30 a.m. Sunday, April 18, online. The event will feature stars of the Israeli Netflix series “Fauda.” Free. ....

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