ஹைடெல்பெர்க் நிறுவனம் க்கு தண்டு செல் தொழில்நுட்பம் News Today : Breaking News, Live Updates & Top Stories | Vimarsana

Stay updated with breaking news from ஹைடெல்பெர்க் நிறுவனம் க்கு தண்டு செல் தொழில்நுட்பம். Get real-time updates on events, politics, business, and more. Visit us for reliable news and exclusive interviews.

Top News In ஹைடெல்பெர்க் நிறுவனம் க்கு தண்டு செல் தொழில்நுட்பம் Today - Breaking & Trending Today

Single Cell Transcriptomics Could Help Eradicate Leukemia More Effectively

Single Cell Transcriptomics Could Help Eradicate Leukemia More Effectively
March 1, 2021
Immature blood cells in leukemia [Source: toeytoey2530/Getty Images]
Research from an international collaboration shows that a single-cell omics approach can identify mutational status and characterize gene expression in hematopoietic stem cells from acute myeloid leukemia patients and successfully identify disease causing cells.
Treatments exist for acute myeloid leukemia (AML), but while these often succeed initially, patients often relapse. Indeed, less than 15% of patients over the age of 60 survive for 5 years after treatment for this reason.
“Only cancer stem cells, residing at the top of the hierarchy, are able to fuel long-term cancer growth and drive relapse, whereas the bulk of the cancer consists of rapidly dividing cells with limited capacity for self-renewal,” write the researchers in the journal article describing the study in ....

Comunidad Autonoma De Cataluna , Lars Velten , Lars Steinmetz , Heidelberg Institute For Stem Cell Technology , Centre For Genomic Regulation , European Molecular Biology Laboratory In Heidelberg , Group Leader , Stanford University , Genomic Regulation , European Molecular Biology Laboratory , Heidelberg Institute , Stem Cell Technology , Experimental Medicine , Nature Genetics , காமுனிடட தன்னாட்சி டி கடலுள் , லார்ஸ் சிடேன்மேடஜ் , ஹைடெல்பெர்க் நிறுவனம் க்கு தண்டு செல் தொழில்நுட்பம் , ஐரோப்பிய மூலக்கூறு உயிரியல் ஆய்வகம் இல் ஹைடெல்பெர்க் , குழு தலைவர் , ஸ்டான்போர்ட் பல்கலைக்கழகம் , ஐரோப்பிய மூலக்கூறு உயிரியல் ஆய்வகம் , ஹைடெல்பெர்க் நிறுவனம் , தண்டு செல் தொழில்நுட்பம் , சோதனை மருந்து , இயற்கை ஜெநெடிக்ஸ் ,

How blood stem cells maintain their lifelong potential for self-renewal

E-Mail
A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) have now discovered in mice that cells in the so-called stem cell niche are responsible for this: Blood vessel cells of the niche produce a factor that stimulates blood stem cells and thus maintains their self-renewal capacity. During aging, production of this factor ceases and blood stem cells begin to age.
Throughout life, blood stem cells in the bone marrow ensure that our body is adequately supplied with mature blood cells. If there is no current need for cell replenishment, the blood stem cells remain in a deep sleep to protect themselves from damage to the genome, which can lead to cancer. Blood loss, infections and inflammations act like an alarm clock: immediately, the blood stem cel ....

Baden Wuberg , Patrick Mehlen , Claudia Korn , Nina Cabezas Wallscheid Andreas Trumpp , Benjamin Gibert , Agnes Hotz Wagenblatt , Nicolas Rama , Jasper Panten , Manon Tourbez , Maria Maryanovich , Simon Mendez Ferrer , Leonid Bystrykh , Pia Sommerkamp , Andreas Trumpp , Erik Zwart , Maik Brune , Dachuan Zhang , Mathias Heikenw , Arthur Flohr Svendsen , Daniel Klimmeck , Benjamin Ducarouge , Bertien Dethmers Ausema , Markus Sohn , Anna Rita Redavid , Pauls Frenette , Adriana Przybylla ,