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Leducq Foundation provides $7 million to support Cardiac Splicing as a Therapeutic Target project

Leducq Foundation provides $7 million to support Cardiac Splicing as a Therapeutic Target project
Diverse messenger RNAs are produced in cells by “alternative splicing.” The Leducq Foundation is now supporting a transatlantic network dedicated to investigating this process in heart muscle cells and how changes in this process contribute to disease. Professor Michael Gotthardt of the MDC and Professor Leslie Leinwand of the University of Colorado Boulder are coordinating the project.
Despite advances in prevention and therapy, cardiovascular diseases are still one of the leading causes of death worldwide. Scientists have only recently begun to understand the key role of alternative splicing - the stitching together of messenger RNA during gene transcription - in cardiovascular diseases. The Leducq Foundation is providing 7 million U.S. dollars over the next five years to support the Cardiac Splicing as a Therapeutic Target (CASTT) project, which is comprised of six E ....

United States , France General , Max Delbr , Emily Henderson , Jean Leducq , Benjamin Meder , Maria Carmo Fonseca , Michael Gotthardt , Leslie Leinwand , Lars Steinmetz , Euan Ashley , University Of Lisbon , Helmholtz Association , University Of Colorado Boulder , Biofrontiers Institute At University Of Colorado Boulder , Leducq Foundation , Stanford University , Heidelberg University Hospital , Professor Leslie Leinwand , Colorado Boulder , Cardiac Splicing , Therapeutic Target , Molecular Medicine , North American Coordinator , Professor Euan Ashley , Professor Maria Carmo Fonseca ,

$7 million to advance cardiovascular research

$7 million to advance cardiovascular research
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , France General , Baden Wüberg , Max Delbr , Jean Leducq , Benjamin Meder , Michael Gotthardt , Maria Carmo Fonseca , Leslie Leinwand , Lars Steinmetz , Euan Ashley , University Of Lisbon , University Of Colorado Boulder , Biofrontiers Institute , Leducq Foundation , Berlin Institute Of Health , German Center , Heidelberg University Hospital , Clinical Research Center , Helmholtz Association , Cardiovascular Research , Biofrontiers Institute At University Of Colorado Boulder , Cardiovascular Cell Biology Lab , Stanford University , Cardiac Splicing , Therapeutic Target ,

SARS-CoV-2 curtails immune response in gut

Scientists transform human intestinal cells into ‘mini guts’ to follow infection process
The researchers were able to monitor the virus’s growth in organoids derived from human intestinal cells. Pink and red show areas of SARS-CoV-2 infection. Credit: Mohammed Shahraz, Sergio Triana/EMBL; Camila Metz-Zumaran/Heidelberg University
EMBL scientists, together with collaborators from Heidelberg University, have provided further evidence of the gut’s role in COVID-19.
In an effort to determine the potential for COVID-19 to begin in a person’s gut, and to better understand how human cells respond to SARS-CoV-2, the scientists used human intestinal cells to create organoids – 3D tissue cultures derived from human cells, which mimic the tissue or organ from which the cells originate. Their conclusions, published in the journal Molecular Systems Biology, indicate the potential for infection to be harboured in a host’s intestines and reveal intricacies in the immu ....

Lars Steinmetz , Mohammed Shahraz , Theodore Alexandrov , Sergio Triana , Camila Metz Zumaran Heidelberg University , Heidelberg University , Molecular Systems Biology , லார்ஸ் சிடேன்மேடஜ் , ஹைடெல்பெர்க் பல்கலைக்கழகம் , மூலக்கூறு அமைப்புகள் உயிரியல் ,

SARS-CoV-2 Disrupts the Immune Response in Intestinal Organoids

SARS-CoV-2 Disrupts the Immune Response in Intestinal Organoids
April 27, 2021
The researchers were able to monitor the virus s growth in organoids derived from human intestinal cells. Pink and red show areas of SARS-CoV-2 infection.
[Mohammed Shahraz, Sergio Triana/EMBL; Camila Metz-Zumaran/Heidelberg University]
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The respiratory tract is given much attention when studying SARS-CoV-2 infection. However, COVID-19 patients show systemic manifestation of the disease in multiple organs. There is clear evidence, for example, of SARS-CoV-2 replication in the gastrointestinal (GI) tract. In an effort to determine the potential for COVID-19 to begin in a person’s gut, and to better understand how human cells respond to SARS-CoV-2, researchers used human intestinal cells to create organoids 3D tissue cultures derived from human cells which mimic the tissue or organ from which the cells originate. Their single-cell analysis data suggest that SARS-CoV-2 infection ....

Baden Wüberg , Lars Steinmetz , Sergio Triana , Theodore Alexandrov , Molecular Systems Biology , Targeted Perturb Seq , லார்ஸ் சிடேன்மேடஜ் , மூலக்கூறு அமைப்புகள் உயிரியல் ,

SARS-CoV-2 suppresses the immune response in the gut

SARS-CoV-2 suppresses the immune response in the gut
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

Lars Steinmetz , Theodore Alexandrov , Sergio Triana , Emily Henderson , Alexandrov Team , European Molecular Biology Laboratory , Molecular Systems Biology , Study Lead Author , Doctoral Candidate , European Molecular Biology , Targeted Perturb Seq , லார்ஸ் சிடேன்மேடஜ் , எமிலி ஹென்டர்சன் , ஐரோப்பிய மூலக்கூறு உயிரியல் ஆய்வகம் , மூலக்கூறு அமைப்புகள் உயிரியல் , படிப்பு வழி நடத்து நூலாசிரியர் , முனைவர் வேட்பாளர் , ஐரோப்பிய மூலக்கூறு உயிரியல் ,