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Novel CRISPR Tool Activates Instead of Editing Human Immune Cell Genes

A research team used a method called CRISPRa to activate each gene in the genome in different cells, enabling them to test almost 20,000 genes in parallel. This allowed them to quickly learn the rules about which genes provide the most powerful levers to reprogram cell functions in ways that could eventually lead to more powerful immunotherapies.
Ralf Schmidt Zachary Steinhart Alex Marson Innovative Genomics Institute Institute Of Genomic Immunology Marson Lab

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Friday News: Domestic Terrorist

CARY INSURRECTIONIST BACK WHERE HE BELONGS, IN FEDERAL CUSTODY: On Jan. 6, 2021, when prosecutors say James Grant led the first assault on the U.S. Capitol, the North Carolina man wore a baseball cap with an insignia that bore a map of his home state, along with these words: “Drink Local.” Last month, Grant did just that. Now he’s going back to jail. On Dec. 7, after a bizarre
United States North Carolina New Hanover Regional Medical Center Jeff Bezos Stanford Mark Davis Rothwell Jacob Simmons
Source: bluenc.com

Gene Editing Expands to New Types of Immune Cells

Gene Editing Expands to New Types of Immune Cells Gladstone researchers fine-tuned CRISPR-Cas9 genome editing to work on human immune cells called monocytes News provided by Share this article Share this article SAN FRANCISCO, May 11, 2021 /PRNewswire/ -- In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have added human...
United States San Francisco Michaelj Mcgregor Chan Zuckerberg Biohub Satishk Pillai David Wu

New method helps map the specialized diversity and spatial location of cells within a tissue or tumor

New method helps map the specialized diversity and spatial location of cells within a tissue or tumor Not all cancer cells within a tumor are created equal; nor do all immune cells (or all liver or brain cells) in your body have the same job. Much of their function depends on their location. Now, researchers at Gladstone Institutes, UC San Francisco (UCSF), and UC Berkeley have developed a more efficient method than ever before to simultaneously map the specialized diversity and spatial locatio...
Eric Chow Youjin Lee Derek Bogdanoff Emily Henderson Alex Marson Institute Of Genomic Immunology

XYZeq: A better map of cell diversity

 E-Mail SAN FRANCISCO, CA--April 21, 2021--Not all cancer cells within a tumor are created equal; nor do all immune cells (or all liver or brain cells) in your body have the same job. Much of their function depends on their location. Now, researchers at Gladstone Institutes, UC San Francisco (UCSF), and UC Berkeley have developed a more efficient method than ever before to simultaneously map the specialized diversity and spatial location of individual cells within a tissue or a tumor. The tech...
United States San Francisco Codyt Mowery Joshua Cantlon Theodorel Roth Youjin Lee

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