Page 30 - Confidence Interval News Today

1. In this target emulation trial, parathyroidectomy did not affect long-term renal function in adults with primary hyperparathyroidism (PHPT). 2. Patients with parathyroidectomy had no difference in the estimated glomerular filtration rate (eGFR) decline compared to those without parathyroidectomy. Evidence Rating Level: 1 (Excellent) Study Rundown: The definitive treatment for PHPT is parathyroidectomy to remove

1. In this randomized controlled trial, endovascular thrombectomy resulted in better functional outcomes than medical care in patients with large ischemic strokes. 2. For patients with large ischemic strokes, endovascular thrombectomy was associated with more vascular complications than medical care. Evidence Rating Level: 1 (Excellent) Study Rundown: Endovascular thrombectomy has been shown to be more

1. In this propensity score–matched cohort study, early treatment with monoclonal antibodies for outpatients with coronavirus disease 2019 (COVID-19) was associated with a lower risk of hospitalization. 2. Early treatment with monoclonal antibodies for COVID-19 showed similar effects across COVID-19 variants. Evidence Rating Level: 1 (Excellent) Study Rundown: Monoclonal antibody treatment has been authorized for

1. In this retrospective cohort study, the inclusion of functional impairment and phenotypic frailty more accurately predicted healthcare costs in Medicare patients than claims-based indicators alone. 2. A greater number of self-reported functional impairments were associated with more significant incremental costs compared to those without functional impairments. Evidence Rating Level: 3 (Average) Study Rundown: Older

1. In this randomized controlled trial, patients with acute strokes secondary to large infarctions had improved disability outcomes with endovascular therapy compared to those with medical therapy alone. 2. Endovascular therapy was also associated with a higher risk of intracranial hemorrhage as a complication. Evidence Rating Level: 1 (Excellent) Study Rundown: Endovascular therapy has become

1. In this randomized trial, postexposure prophylactic doxycycline significantly reduced the incidence of sexually transmitted infections (STIs) in men who have sex with men (MSM) and transgender women. 2. Postexposure prophylaxis with doxycycline was not associated with an increased risk of serious adverse events. Evidence Rating Level: 1 (Excellent) Study Rundown: MSM and transgender women

1. In this randomized controlled trial, a single dose of azithromycin reduced the risk of maternal sepsis or death among women in labor planning a vaginal birth as compared to a placebo. 2. Azithromycin use was not associated with a decreased risk of stillbirth, neonatal death, or neonatal sepsis. Evidence Rating Level: 1 (Excellent) Study

1. In this randomized controlled trial, the effects of thromboprophylaxis on clinical outcomes after coronavirus disease 2019 (COVID-19) hospitalization were inconclusive due to early termination of enrollment. 2. The incidence of death or thromboembolism was low in this cohort of patients discharged following COVID-19 hospitalization. Evidence Rating Level: 3 (Average) Study Rundown: Prior studies have

1. In this randomized controlled trial, vedolizumab induced remission in patients with chronic pouchitis after undergoing ileal pouch-anal anastomosis (IPAA) for ulcerative colitis as compared to a placebo. 2. The incidence of overall and severe adverse events was comparable between groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Restorative proctocolectomy with IPAA is routinely performed

1. In this randomized controlled trial, closed-loop insulin delivery was more effective than standard care in keeping blood glucose levels within target for children aged two to six with type 1 diabetes. 2. Closed-loop insulin delivery was also superior to standard care regarding the percentage of time in the hyperglycemic/hypoglycemic range, mean glucose levels, and