ASCO GU 2020: PSMA-targeted 18F-DCFPyL PET/CT Imaging in Patients with Prostate Cancer (OSPREY) San Francisco, California (UroToday.com) In this oral abstract, the author presented results from Cohort A of the OSPREY trial (NCT02981368) looking at the diagnostic performance of the PSMA-PET radiopharmaceutical 18F-DCFPyL in 252 high-risk prostate cancer patients who are to undergo radical prostatectomy with lymphadenectomy. This tracer is owned by Progenics Pharmaceuticals, Inc, and is similar to other PSMA-PET radiopharmaceuticals available such as 68Ga (Gallium-68), though the 18F radioisotope may have favorable nuclear decay properties. PSMA is a transmembrane glycoprotein that is expressed in primary and metastatic prostate adenocarcinoma, but not neuroendocrine carcinoma. Utilizing the PSMA protein in PET/CT prostate diagnosis is of interest given the limited utility of conventional 18F-FDG PET/CT. Available data suggests that PSMA targeting PET imaging may perform better in prostate cancer relative to other PET tracers such as choline and fluciclovine. This data, however, has been limited as it is from largely retrospective analyses or single center prospective studies.