Can you get a different COVID-19 vaccine later if you’re unhappy with the shot you got? Health experts say not much is known about how different vaccines interact with each other, so shots should be taken as they were studied. Used Pfizer-BioNTech COVID-19 vaccine vials rest in a blue tray at Ellis Davis Fieldhouse, a Parkland Hospital testing and vaccine location, in Dallas on Wednesday, March 3, 2021. (Lola Gomez/The Dallas Morning News)(Lola Gomez / Staff Photographer) With three COVID-19 vaccines approved in the U.S. and more possibly on the way, many people are wondering which vaccine is right for them — or whether mixing and matching the shots may provide better long-term protection.