Cherokee Trail of Tears just one of many forced removals of Eastern tribes to Oklahoma WASHINGTON – The Trail of Tears, the forced removal of the Cherokee Nation to Oklahoma, was one of the most inhumane policies in American history – but it wasn’t an isolated incident. In 1831, nearly 16,000 members of the Cherokee Nation were forced under armed guard to leave their native lands in the southeastern United States to trek more than 1,000 miles to what eventually would become the state of Oklahoma. Almost 4,000 Cherokees died along the way, never making it to the land designated by the U.S. government as Indian Territory.