can be signs of a life -threatening condition. side effects may include allergic reactions, neck and injection site pain, fatigue, and headache. don't take botox® if there's a skin infection. tell your doctor your medical history, muscle or nerve conditions, and medications, including botulinum toxins, as these may increase the risk of serious side effects. with the botox® savings program, most people with commercial insurance pay nothing out-of-pocket. talk to your doctor and visit botox®cmsavings.com to enroll.