Feb 12, 2021 Multiple measures of group A Streptococcus (GAS) exposure were unrelated to tic exacerbations in children with chronic tic disorders (CTD), including Tourette syndrome, a prospective cohort study found. “Specific work-up or active management of GAS infections is unlikely to help modify the course of tics in CTD and is therefore not recommended,” wrote Davide Martino, MD, PhD, of the University of Calgary in Canada, and co-authors in In 715 children with CTD who had mean age of 10.7 and who mostly (77%) were boys, researchers assessed tic, obsessive-compulsive symptoms, and attention deficit/hyperactivity disorder (ADHD) severity through weekly symptom diaries, regular clinic visits, and telephone calls over an average follow-up of 16 months. A clinical assessment visit was done when symptom worsening was reported.