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Natural "brake" against malignant neuroblastoma | EurekAlert! Science News


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IMAGE: Tamara Weiss, PhD, and Sabine Taschner-Mandl, PhD, discover that the uncontrolled growth of neuroblastomas (green tumor cells) is stopped by a signal molecule produced by Schwann cells (magenta).
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Credit: Photo: Sabine Taschner-Mandl, PhD, and Tamara Weiss, PhD
Copyright: St. Anna Children s Cancer Research Institute
Image: Immunofluorescence image of Schwann cells (magenta) and neuroblastoma cells (green)
Copyright: Weiss T, Taschner-Mandl S et al.,.
A factor that turns malignant tumors into benign ones? - That is exactly what scientists at St. Anna Children s Cancer Research Institute have discovered. Together with colleagues from the Medical University of Vienna and the University of Vienna (Faculty of Chemistry), they studied tumors of the peripheral nervous system in children, namely neuroblastomas. The scientists discovered that the uncontrolled growth of benign neuroblastomas is stopped by a signal molecule p ....

Eteläuomen Läi , United Kingdom , Baden Wuberg , Fikret Rifatbegovic , Florian Kromp , Peterf Ambros , Reinhard Windhager , Maximiliano Kauer , Christopher Gerner , Ingem Ambros , Christian Frech , Herzfeldersche Familienstiftung , Helena Sorger , Sabine Taschner Mandl , Andrea Bileck , Tamara Weiss , Lukas Janker , European Union Seventh Framework Program , Marie Curie Program , Nature Communications , Vienna University Of Technology , Institute Of Immunology , Anne Mclaren Laboratory For Regenerative Medicine , University Of Cambridge , Cambridge Stem Cell Institute , Coin Networks ,

Group A Strep Not Associated with Tic Exacerbation


Feb 12, 2021
Multiple measures of group A
Streptococcus (GAS) exposure were unrelated to tic exacerbations in children with chronic tic disorders (CTD), including Tourette syndrome, a prospective cohort study found.
“Specific work-up or active management of GAS infections is unlikely to help modify the course of tics in CTD and is therefore not recommended,” wrote Davide Martino, MD, PhD, of the University of Calgary in Canada, and co-authors in
In 715 children with CTD who had mean age of 10.7 and who mostly (77%) were boys, researchers assessed tic, obsessive-compulsive symptoms, and attention deficit/hyperactivity disorder (ADHD) severity through weekly symptom diaries, regular clinic visits, and telephone calls over an average follow-up of 16 months. A clinical assessment visit was done when symptom worsening was reported. ....

United States , Keith Coffman , Paul Smyth , Andrea Cavanna , Michaelp Smith , Davide Martino , European Union Seventh Framework Program , Dystonia Medical Research Foundation Canada , Tourette Syndrome Association Of America , University Of Birmingham , University Of Calgary , European Union , Dystonia Medical Research Foundationcanada , Canadian Institutes For Health Research , Parkinson Association Of Alberta , Owerko Foundation , Movement Disorders Society , Mercy Hospital , Kansas City , Yale Global Tic Severity Scale , Contributing Writer , Tourette Syndrome Association , Michaelp Smith Family , Ipsen Corporate , Parkinson Association , Canadian Institutes ,