Health care workers caring for patients with COVID-19 are at risk for infection. What is added by this report? In April 2020, U.S. military personnel were deployed to a New York City field hospital to care for COVID-19 patients. A robust infection control plan was implemented and enforced. Among 336 soldiers participating in an infection risk study, the overall infection rate was 1.7%; the rate among those involved in direct patient care was 0.9%. What are the implications for public health practice? A well-designed and well-implemented infection control plan and use of adequate personal protective equipment can mitigate the risk for SARS-CoV-2 transmission in health care settings, including nontraditional settings.