E-Mail An analysis of the first wave of the epidemic in Iran in 8902 people suggests the overall proportion of people with SARS-CoV-2 antibodies in their blood - known as seroprevalence - may be higher than rates based on clinical cases alone, at around 17.1% seropositivity vs 0.6% based on modelling from previous studies, by end of April 2020. However, seroprevalence varies widely between cities - with the highest estimates found in Rasht (72.6%) and the lowest in Sanandaj (1.7%) although some cities had small samples sizes. Despite high seroprevalence in a few cities, a large proportion of population is still uninfected. The potential shortcomings of current public health policies should therefore be identified to prevent future epidemic waves in Iran.