25 January, 2021 Vaccines use components of infectious agents such as bacteria and viruses to stimulate the body’s immune system to recognise and mark them for destruction, preventing the infectious agents from replicating and causing infection. This article is the fifth in a six-part series about the lymphatic system Abstract This article, the fifth in a six-part series on the lymphatic system, examines the role of antibodies in developing immunity to infectious viruses and bacteria. It also summarises the history of vaccine development and explains how different vaccines stimulate an immune response. Citation: Knight J, Nigam Y (2021) The lymphatic system 5: vaccinations and immunological memory.