test subjects were vaccinated against hepatitis half the group were then allowed to go to bed while the others had to stay awake until the next evening blood tests then revealed that the individuals who had to stay away had only half as many antibodies and were thus more susceptible to getting sick. of course laughs like insufficient sleep has an effect on the cardiovascular system and we know for example that patients with a higher predisposition develop high blood pressure we also know that a higher rate of depression and anxiety comes with sleep deprivation and you know my shut off. recent research suggests that chronic sleep deprivation can raise the risk of brain disease. vanished also actions like when you don't sleep enough the toxic waste generated in the brain doesn't get cleared away as it should be and that build up can be conducive to diseases like dementia and parkinson's.