have an increased risk of death or stroke. call your doctor about unusual changes in behavior or suicidal thoughts. antidepressants can increase these in children and young adults. report fever, stiff muscles, or confusion, which may mean a life-threatening reaction, or uncontrollable muscle movements, may be permanent. side effects may not appear for several weeks. metabolic changes may occur. movement dysfunction, restlessness, sleepiness, stomach issues are common side effects. when bipolar i overwhelms, vraylar helps smooth the ups and downs.