By Dr. C.D. Sreenivasa Murthy It was in March 2020 India took many harsh measures and enforced lockdowns which gradually reduced the incidence of Covid disease. As the country was feeling happy by the beginning of 2021, and slowly relaxed many restrictions, covid-19 disease has returned with greater fury and virulence. All over the world including India, vaccine discovery and production was encouraged by the Governments. From the available data, all the vaccines presently used in many countries appear to be mostly safe and extremely efficacious. Even when there is an occasional breakthrough infection, the vaccines mitigate the effects of the disease reducing hospitalisation and mostly preventing death. So emphasis on vaccination is on the minds of the health care policy-makers. In this article some of the frequently raised doubts and questions are being discussed.