Which biomarkers can help predict severe COVID-19? The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to over 119 million confirmed cases and over 2.6 million deaths so far. Even as vaccines are being rolled out in many countries, supply challenges and cold-chain obstacles are likely to slow down the pace of universal immunization, favoring the emergence of novel vaccine-resistant strains. The ability to detect potentially fatal illness early on in the course of the disease would enable a swift prioritization of these high-risk individuals for treatment. A new preprint on the medRxiv* server presents an array of biomarkers that may help achieve this laudable goal.