(3) PJSC Pharmsynthez is leveraging Xenetic's PolyXen® technology to improve the pharmacological properties of its Epolong product candidate pursuant to a royalty-bearing collaboration agreement Russian registration filing of Epolong, a polysialylated form of recombinant human erythropoietin, follows previously reported positive Phase 3 data for the treatment of anemia in patients with chronic kidney disease FRAMINGHAM, MA / ACCESSWIRE / February 16, 2021 / Xenetic Biosciences, Inc. (NASDAQ:XBIO) ("Xenetic" or the "Company"), a biopharmaceutical company focused on advancing XCART, a personalized CAR T platform technology engineered to target patient- and tumor-specific neoantigens, today announced its partner, PJSC Pharmsynthez ("Pharmsynthez"), has reported in a press release that it has started the registration phase of Epolong (erythropoietin and polysialic acid conjugate) by filing a registration dossier to obtain approval of Epolong in Russia for the treatment of anemia in patients with chronic kidney disease. The registration dossier is based on previously reported data from Pharmsynthez's Phase 3 clinical trials of Epolong in Russia, which reportedly demonstrated the efficacy of Epolong and its potential to reduce side effects. Pharmsynthez is leveraging Xenetic's PolyXen® technology to improve the pharmacological properties of its Epolong product candidate pursuant to a royalty-bearing collaboration agreement between the Company's wholly-owned subsidiary, Lipoxen Technologies Limited, and Pharmsynthez's wholly-owned subsidiary, SynBio LLC.