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Abstract The compelling need to provide adoptive cell therapy (ACT) to an increasing number of oncology patients within a meaningful therapeutic window makes the development of an efficient, fast, versatile, and safe genetic tool for creating recombinant T cells indispensable. In this study, we used nonintegrating minimally sized DNA vectors with an enhanced capability of generating genetically modified cells, and we demonstrate that they can be efficiently used to engineer human T lymphocytes. This vector platform contains no viral components and is capable of replicating extrachromosomally ...

+CD27 + B cells at each sampling time point (top). Mean frequencies of SARS-CoV-2 S-specific B cells expressing the indicated isotype in mild and severe donors (bottom). Error bars denote standard deviation and black bars indicate means. (F) Proportion of SARS-CoV-2 S-specific swIg + B cells that express CD71 at each sampling time point (top). Mean frequencies of SARS-CoV-2 S-specific swIg +CD71 + B cells in mild and severe donors (bottom). Error bars denote standard deviation and black bars indicate means. The dotted line indicates the level of CD71 expression on swIg + B cells in pre-pandem...