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Trophic eggs affect caste determination in the ant Pogonomyrmex rugosus

Trophic eggs affect caste determination in the ant Pogonomyrmex rugosus
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

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Epitope editing enables targeted immunotherapy of acute myeloid leukaemia

Despite the considerable efficacy observed when targeting a dispensable lineage antigen, such as CD19 in B cell acute lymphoblastic leukaemia1,2, the broader applicability of adoptive immunotherapies is hampered by the absence of tumour-restricted antigens3–5. Acute myeloid leukaemia immunotherapies target genes expressed by haematopoietic stem/progenitor cells (HSPCs) or differentiated myeloid cells, resulting in intolerable on-target/off-tumour toxicity. Here we show that epitope engineering of donor HSPCs used for bone marrow transplantation endows haematopoietic lineages with selective resistance to chimeric antigen receptor (CAR) T cells or monoclonal antibodies, without affecting protein function or regulation. This strategy enables the targeting of genes that are essential for leukaemia survival regardless of shared expression on HSPCs, reducing the risk of tumour immune escape. By performing epitope mapping and library screenings, we identified amino acid changes that abr ....

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Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , Sakura Finetek , Zeiss Axiovert , Qiagen Rneasy , Vicryl Ethicon , National Institutes Of Health , Division Of Comparative Medicine , Lunenfeld Tanenbaum Research Institute Sequencing Facility Toronto , Collibri Library Quantification Kit Thermo Fisher Scientific , National Institute Of Health , Research Ethics Board , University Of Toronto Animal Care Committee , Illumina Nextera Xt Library Prep Kit , Data Processing Software , University Of Toronto , Ge Healthcare , Lab Co , Glogauer University Of Toronto , University Of Toronto Fellowship , Bh Software , Ontario Student Opportunity Trust Funds Award , Kingfisher Biotech , Toronto Animal Care Committee , Viagen Biotech , Master Mix , Thermo Fisher Scientific ,

Nucleic acid analysis for sample quality assessment using the Agilent Fragment Analyzer Systems

In this application compendium, Agilent Technologies introduces the use of its Fragment Analyzer Systems for nucleic acid analysis and sample quality assessment. The Fragment Analyzer Systems offer a wide range of application kits, enabling easy sizing, qualification, and quantification of both DNA and RNA samples. Additionally the compendium also provides a brief overview of capillary electrophoresis technology and the product portfolio of Fragment Analyzer Systems. ....

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Fragment Analyzer Systems from Agilent Technologies

Read independent reviews on Fragment Analyzer Systems from Agilent Technologies on SelectScience ....

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